The Journal of Heart and Lung Transplantation
Volume 27, Issue 3 , Pages 297-301 , March 2008

Clinical Implications and Longitudinal Alteration of Peripheral Blood Transcriptional Signals Indicative of Future Cardiac Allograft Rejection

  • Mandeep R. Mehra, MD

      Affiliations

    • Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationReprint requests: Mandeep R. Mehra, MD, Division of Cardiology, University of Maryland School of Medicine, S3B06, 22 South Greene Street, Baltimore, MD 21201. Telephone: 410-328-7716. Fax: 410-328-4352.
    • ,
  • Jon A. Kobashigawa, MD

      Affiliations

    • University of California at Los Angeles, Los Angeles, California
    • ,
  • Mario C. Deng, MD

      Affiliations

    • Columbia University, New York, New York
    • ,
  • Kenneth C. Fang, MD

      Affiliations

    • XDx, Inc., Brisbane, California
    • ,
  • Tod M. Klingler, PhD

      Affiliations

    • XDx, Inc., Brisbane, California
    • ,
  • Preeti G. Lal, PhD

      Affiliations

    • XDx, Inc., Brisbane, California
    • ,
  • Steven Rosenberg, PhD

      Affiliations

    • XDx, Inc., Brisbane, California
    • ,
  • Patricia A. Uber, PharmD

      Affiliations

    • Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Randall C. Starling, MD

      Affiliations

    • Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Srinivas Murali, MD

      Affiliations

    • Allegheny General Hospital, Pittsburgh, Pennsylvania
    • ,
  • Daniel F. Pauly, MD

      Affiliations

    • University of Florida, Gainesville, Florida
    • ,
  • Russell Dedrick, PhD

      Affiliations

    • XDx, Inc., Brisbane, California
    • ,
  • Michael G. Walker, PhD

      Affiliations

    • XDx, Inc., Brisbane, California
    • ,
  • Adriana Zeevi, PhD

      Affiliations

    • University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Howard J. Eisen, MD

      Affiliations

    • Drexel University College of Medicine, Philadelphia, Pennsylvania.
    • ,
  • CARGO Investigators

Received 14 September 2007 ,Revised 26 November 2007 ,Accepted 28 November 2007.

References 

  1. Kaczmarek I, Ertl B, Schmauss D, et al. Preventing cardiac allograft vasculopathy: long-term beneficial effects of mycophenolate mofetil. J Heart Lung Transplant. 2006;25:550–556
  2. Topkara VK, Dang NC, John R, et al. A decade experience of cardiac retransplantation in adult recipients. J Heart Lung Transplant. 2005;24:1745–1750
  3. Deng MC, Eisen HJ, Mehra MR, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6:150–160
  4. Starling RC, Pham M, Valantine H, et al. Molecular testing in the management of cardiac transplant recipients: initial clinical experience. J Heart Lung Transplant. 2006;25:1389–1395
  5. Yamani MH, Taylor DO, Rodriguez ER, et al. Transplant vasculopathy is associated with increased AlloMap gene expression score. J Heart Lung Transplant. 2007;26:403–406
  6. Mehra MR, Kobashigawa JA, Deng MC, et al. Transcriptional signals of T cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts. J Heart Lung Transplant. 2007;26:1255–1263
  7. Galon J, Franchimont D, Hiroi N, et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J. 2002;16:61–71
  8. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710–1720
  9. Hunter DJ, Kraft P. Drinking from the fire hose—statistical issues in genomewide association studies. N Engl J Med. 2007;357:436–439
  10. Ioannidis JP, Patsopoulos NA, Evangelou E. Heterogeneity in meta-analyses of genome-wide association investigations. PLoS Med. 2007;2:e841

 Supported by a grant from XDx, Inc. Some of the authors received consulting fees or research grant support from XDx, Inc., whereas others were in the employment of XDx, Inc., during the development of this work.

PII: S1053-2498(07)01455-6

doi: 10.1016/j.healun.2007.11.578

The Journal of Heart and Lung Transplantation
Volume 27, Issue 3 , Pages 297-301 , March 2008

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