The Journal of Heart and Lung Transplantation
Volume 26, Issue 10 , Pages 1048-1053 , October 2007

Donor Cardiac Troponin I Levels Do Not Predict Recipient Survival After Cardiac Transplantation

  • Kiran K. Khush, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco, California
    • Corresponding Author InformationReprint requests: Kiran K. Khush, MD, 505 Parnassus Ave, Box 0124, San Francisco, CA 94143. Telephone: 415-476-0626. Fax: 415-476-0424
    • ,
  • Rebecca L. Menza, ACNP, MS

      Affiliations

    • California Transplant Donor Network, Oakland, California.
    • ,
  • Wayne D. Babcock, RN

      Affiliations

    • California Transplant Donor Network, Oakland, California.
    • ,
  • Jonathan G. Zaroff, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco, California

Received 9 July 2006 ,Revised 7 January 2007 ,Accepted 15 July 2007.

References 

  1. Potapov EV, Ivanitskaia EA, Loebe M, et al. Value of cardiac troponin I and T for selection of heart donors and as predictors of early graft failure. Transplantation. 2001;71:1394–1400
  2. Deibert E, Aiyagari V, Diringer MN. Reversible left ventricular dysfunction associated with raised troponin I after subarachnoid haemorrhage does not preclude successful heart transplantation. Heart. 2000;84:205–207
  3. Taylor DO, Edwards LB, Boucek MM, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report--2005. J Heart Lung Transplant. 2005;24:945–955
  4. Costanzo MR, Augustine S, Bourge R, et al. Selection and treatment of candidates for heart transplantation (A statement for health professionals from the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association). Circulation. 1995;92:3593–3612
  5. Gridelli B, Remuzzi G. Strategies for making more organs available for transplantation. N Engl J Med. 2000;343:404–410
  6. Mokadam NA, Ewald GA, Damiano RJ, Moazami N. Deterioration and mortality among patients with United Network for Organ Sharing status 2 heart disease: caution must be exercised in diverting organs. J Thorac Cardiovasc Surg. 2006;131:925–926
  7. Zimmermann R, Baki S, Dengler TJ, et al. Troponin T release after heart transplantation. Br Heart J. 1993;69:395–398
  8. Young JB, Naftel DC, Bourge RC, et al. Matching the heart donor and heart transplant recipient (Clues for successful expansion of the donor pool: a multivariable, multiinstitutional report. The Cardiac Transplant Research Database Group). J Heart Lung Transplant. 1994;13:353–364discussion 364–5
  9. Hosenpud JD, Novick RJ, Breen TJ, Keck B, Daily P. The Registry of the International Society for Heart and Lung Transplantation: twelfth official report--1995. J Heart Lung Transplant. 1995;14:805–815
  10. Christenson RH, Duh SH, Newby LK, et al. Cardiac troponin T and cardiac troponin I: relative values in short-term risk stratification of patients with acute coronary syndromes (GUSTO-IIa Investigators). Clin Chem. 1998;44:494–501
  11. Stubbs P, Collinson P. Cardiac troponins in acute coronary syndromes. N Engl J Med. 1997;336:1257–1258author reply 1258–9
  12. Zaroff JG, Babcock WD, Shiboski SC, Solinger LL, Rosengard BR. Temporal changes in left ventricular systolic function in heart donors: results of serial echocardiography. J Heart Lung Transplant. 2003;22:383–388
  13. Wheeldon DR, Potter CD, Oduro A, Wallwork J, Large SR. Transforming the “unacceptable” donor: outcomes from the adoption of a standardized donor management technique. J Heart Lung Transplant. 1995;14:734–742
  14. Szabo G, Hackert T, Sebening C, Vahl CF, Hagl S. Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death. Ann Thorac Surg. 1999;67:18–25discussion 25–6
  15. Mayer SA, LiMandri G, Sherman D, et al. Electrocardiographic markers of abnormal left ventricular wall motion in acute subarachnoid hemorrhage. J Neurosurg. 1995;83:889–896
  16. Seiler C, Laske A, Gallino A, Turina M, Jenni R. Echocardiographic evaluation of left ventricular wall motion before and after heart transplantation. J Heart Lung Transplant. 1992;11:867–874
  17. Zaroff JG, Rosengard BR, Armstrong WF, et al. Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28–29, 2001, Crystal City, Va. Circulation. 2002;106:836–841
  18. Kono T, Nishina T, Morita H, Hirota Y, Kawamura K, Fujiwara A. Usefulness of low-dose dobutamine stress echocardiography for evaluating reversibility of brain death-induced myocardial dysfunction. Am J Cardiol. 1999;84:578–582
  19. Milano A, Livi U, Casula R, et al. Influence of marginal donors on early results after heart transplantation. Transplant Proc. 1993;25:3158–3159
  20. Riou B, Dreux S, Roche S, et al. Circulating cardiac troponin T in potential heart transplant donors. Circulation. 1995;92:409–414
  21. Vijay P, Scavo VA, Morelock RJ, Sharp TG, Brown JW. Donor cardiac troponin T: a marker to predict heart transplant rejection. Ann Thorac Surg. 1998;66:1934–1939
  22. Miller WL, Edwards BS, Kremers WK, et al. Elevated donor troponin levels are associated with a lower frequency of allograft vasculopathy. J Heart Lung Transplant. 2005;24:2075–2078

PII: S1053-2498(07)00539-6

doi: 10.1016/j.healun.2007.07.026

The Journal of Heart and Lung Transplantation
Volume 26, Issue 10 , Pages 1048-1053 , October 2007

Article Tools

* Image Usage & Resolution