The Journal of Heart and Lung Transplantation
Volume 26, Issue 9 , Pages 962-963 , September 2007

Anaphylaxis from Aprotinin Re-Exposure During Heart Transplantation

  • Olga Toleva, MD

      Affiliations

    • Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Anson Cheung, MD, FRCSC

      Affiliations

    • Division of Cardiothoracic Surgery, St. Paul’s Hospital, Vancouver, British Columbia, Canada
    • ,
  • Andrew Ignaszewski, MD, FRCPC

      Affiliations

    • Heart Function Clinic, St. Paul’s Hospital, Vancouver, British Columbia, Canada

References 

  1. Peters DC, Noble S. Aprotinin: an update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery drugs. (233-2600012-6667/99/0002-0233) Auckland, New Zealand: Adis International; 1999;
  2. Scheule AM, Beierlein W, Wendel HP, et al. Fibrin sealant, aprotinin, and immune response in children undergoing operations for congenital heart disease. J Thorac Cardiovasc Surg. 1998;115:883–889
  3. Dietrich W, Späth P, Ebell A, Richter JA. Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart operations.
  4. Scheule AM, Beierlein W, Arnold S, et al. The significance of preformed aprotinin specific antibodies in cardiosurgical patients. Anesth Analg 200;90:262–5.

PII: S1053-2498(07)00520-7

doi: 10.1016/j.healun.2007.07.007

The Journal of Heart and Lung Transplantation
Volume 26, Issue 9 , Pages 962-963 , September 2007

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