The Journal of Heart and Lung Transplantation
Volume 26, Issue 7 , Pages 753-755 , July 2007

Cranial Leiomyosarcoma in an Epstein–Barr Virus (EBV)-mismatched Lung Transplant Recipient

  • Nadia J. Chaves, MD

      Affiliations

    • Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • Tom C. Kotsimbos, MD

      Affiliations

    • Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • Mark A. Warren, MD

      Affiliations

    • Department of Medical Oncology, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • Catriona A. McLean, MD

      Affiliations

    • Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia.
    • ,
  • Denis W. Spelman, MD

      Affiliations

    • Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • Trevor J. Williams, MD

      Affiliations

    • Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • Greg I. Snell, MD

      Affiliations

    • Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • Glen P. Westall, MD

      Affiliations

    • Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • Corresponding Author InformationReprint requests: Glen P. Westall, MD, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, and Monash University Medical School, Melbourne, VIC 3181, Australia. Telephone: +61-3-92762405. Fax: +61-3-92763601.

Received 11 February 2007 ,Revised 18 April 2007 ,Accepted 8 May 2007.

References 

  1. Rogatsch H, Bonatti H, Menet A, et al. Epstein–Barr virus-associated multicentric leiomyosarcoma in an adult patient after heart transplantation: case report and review of the literature. Am J Surg Pathol. 2000;24:614–621
  2. Walker D, Gill TJ, Corson JM. Leiomyosarcoma in a renal allograft recipient treated with immunosuppressive drugs. JAMA. 1971;215:2084–2086
  3. Wu TT, Swerdlow SH, Locker J, et al. Recurrent Epstein–Barr virus-associated lesions in organ transplant recipients. Hum Pathol. 1996;27:157–164
  4. van Gelder T, Jonkman FA, Neisters HG, et al. Absence of Epstein–Barr virus involvement in an adult heart transplant recipient with an epithelioid leiomyosarcoma. J Heart Lung Transplant. 1996;15:650–651
  5. Armas Molina JV, Chesa Ponce N, Martin Betancor D, et al. Bladder leiomyosarcoma in a young man with a transplant (Report of a case). Acta Urol Esp. 1997;21:283–286
  6. Ferlicot S, Bessoud B, Branchereau S, et al. Smooth muscle mesentery associated with Epstein–Barr virus (Report of a case in a child with a liver transplant under FK506 regimen). Ann Pathol. 1999;19:46–49
  7. Brichard B, Smets F, Sokal E, et al. Unusual evolution of an Epstein–Barr virus-associated leiomyosarcoma occurring after liver transplantation. Pediatr Transplant. 2001;5:365–369
  8. Ashfaq A, Haller JE, Mossey R, et al. Recurrent membranous nephropathy and leiomyosarcoma in the renal allograft of a lupus patient. J Nephrol. 2004;17:143–148
  9. Dionne JM, Carter JE, Matsell D. Renal leiomyoma associated with Epstein–Barr virus in a pediatric transplant patient. Am J Kidney Dis. 2005;46:351–355
  10. Bonatti H, Hoefer D, Rogastch H, et al. Successful management of recurrent Epstein–Barr virus-associated multilocular leiomyosarcoma after cardiac transplantation. Transplant Proc. 2005;37:1839–1844
  11. Toh HC, Teo M, Ong KW. Use of sirolimus for Epstein–Barr virus positive smooth muscle tumor. Lancet Oncol. 2006;7:955–957
  12. Somers GR, Tesoriero AA, Hartland E, et al. Multiple leiomyosarcomas of both donor and recipient origin arising in a heart–lung transplant patient. Am J Surg Pathol. 1998;22:1423–1428
  13. Tahri A, Noel G, Figuerella-Branger D. Epstein–Barr associated central nervous system leiomyosarcoma occurring after renal transplantation: case report and review of the literature. Cancer Radiother. 2003;7:308–313
  14. Kaphan E, Eusebio A, Donnet A, et al. Primary leiomyosarcoma of the cavernous sinus associated with Epstein–Barr virus in a kidney graft. Rev Neurol. 2003;159:1055–1059
  15. Boudejemaa S, Boman F, Guigonis V, et al. Brain involvement in multicentric Epstein–Barr virus-associated smooth muscle tumors in a child after kidney transplantation. Virchows Arch. 2004;444:387–391
  16. Fujita H, Kiriyama M, Kawamura T, et al. Primary hepatic leiomyosarcoma in a woman after renal transplantation; report of a case. Surg Today. 2002;32:446–449
  17. Medicott SA, Devlin S, Helmersen D, et al. Early post-transplant smooth muscle neoplasia of the colon presenting as diminutive polyps: a case complicating post-transplant lymphoproliferative disorder. Int J Surg Pathol. 2006;14155–14161
  18. Babel N, Gabdrakhmanova L, Hammer M, et al. Induction of pre-transplant Epstein–Barr virus (EBV) infection by donor blood transfusion in EBV-seronegative recipients may reduce risk of post-transplant lymphoproliferative disease in adolescent renal transplant patients: report of two cases. Transplant Infect Dis. 2005;7:133–136
  19. Wong T, Tait B, Levvey B, et al. Epstein–Barr virus primary mismatching and HLA matching: key risk factors for post lung transplant lymphoproliferative disease. Transplantation. 2004;78:205–210
  20. Gross TG. Treatment of Epstein–Barr virus-associated post-transplant lymphoproliferative disorders. J Paediatr Haematol Oncol. 2001;23:7–9
  21. Gershburg E, Pagano J. Epstein–Barr virus infections: prospects for treatment. J Antimicrob Chemother. 2005;56:277–281
  22. Bakker NA, van Imhoff GW, Werschuuren EA, et al. Presentation and early detection of post-transplant lymphoproliferative disorder after solid organ transplantation. Transplant Int. 2007;20:207–218
  23. Savoldo B, Goss JA, Hammer MM, et al. Treatment of solid organ transplant recipients with autologous Epstein–Barr virus-specific cytotoxic T lymphocytes. Blood. 2006;108:2942–2949
  24. Raj R, Frost AE. Lung re-transplantation after post-transplantation lymphoproliferative disorder (PTLD): a single-center experience and review of literature of PTLD in lung transplant recipients. J Heart Lung Transplant. 2005;24:671–679
  25. Nepomuceno RR, Balatoni CE, Natakunam Y, et al. Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res. 2003;63:4472–4480

PII: S1053-2498(07)00370-1

doi: 10.1016/j.healun.2007.05.007

The Journal of Heart and Lung Transplantation
Volume 26, Issue 7 , Pages 753-755 , July 2007

Article Tools

* Image Usage & Resolution