Cranial Leiomyosarcoma in an Epstein–Barr Virus (EBV)-mismatched Lung Transplant Recipient

Received 11 February 2007; received in revised form 18 April 2007; accepted 8 May 2007.

Leiomyosarcoma is a rare Epstein–Barr virus (EBV)-related complication of solid-organ transplantation. We report the case of a 19-year-old woman with cystic fibrosis who presented with protracted headaches 15 months after an EBV-mismatched bilateral sequential lung transplant. A parasagittal lesion was found on cranial magnetic resonance imaging; surgical resection revealed a leiomyosarcoma. We discuss treatment options of what is, to our knowledge, the first described case of a cranial leiomyosarcoma in a lung transplant recipient.

a Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia

b Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia

c Department of Medical Oncology, Alfred Hospital, Melbourne, Victoria, Australia

d Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia.

Reprint requests: Glen P. Westall, MD, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, and Monash University Medical School, Melbourne, VIC 3181, Australia. Telephone: +61-3-92762405. Fax: +61-3-92763601.

PII: S1053-2498(07)00370-1

doi:10.1016/j.healun.2007.05.007

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