Cranial Leiomyosarcoma in an Epstein–Barr Virus (EBV)-mismatched Lung Transplant Recipient

Chaves, Nadia J.; Kotsimbos, Tom C.; Warren, Mark A.; McLean, Catriona A.; Spelman, Denis W.; Williams, Trevor J.; Snell, Greg I.; Westall, Glen P.

doi:10.1016/j.healun.2007.05.007

« Previous Next »The Journal of Heart and Lung Transplantation
Volume 26, Issue 7 , Pages 753-755, July 2007

Cranial Leiomyosarcoma in an Epstein–Barr Virus (EBV)-mismatched Lung Transplant Recipient

Nadia J. Chaves, MD
- Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
- Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
Tom C. Kotsimbos, MD
- Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
Mark A. Warren, MD
- Department of Medical Oncology, Alfred Hospital, Melbourne, Victoria, Australia
Catriona A. McLean, MD
- Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia.
Denis W. Spelman, MD
- Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
Trevor J. Williams, MD
- Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
Greg I. Snell, MD
- Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
Glen P. Westall, MD
- Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
- Reprint requests: Glen P. Westall, MD, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, and Monash University Medical School, Melbourne, VIC 3181, Australia. Telephone: +61-3-92762405. Fax: +61-3-92763601.

Received 11 February 2007; received in revised form 18 April 2007; accepted 8 May 2007.

Leiomyosarcoma is a rare Epstein–Barr virus (EBV)-related complication of solid-organ transplantation. We report the case of a 19-year-old woman with cystic fibrosis who presented with protracted headaches 15 months after an EBV-mismatched bilateral sequential lung transplant. A parasagittal lesion was found on cranial magnetic resonance imaging; surgical resection revealed a leiomyosarcoma. We discuss treatment options of what is, to our knowledge, the first described case of a cranial leiomyosarcoma in a lung transplant recipient.