The Journal of Heart and Lung Transplantation
Volume 25, Issue 3 , Pages 276-282 , March 2006

Lipid Profiles in Pediatric Thoracic Transplant Recipients are Determined by Their Immunosuppressive Regimens

  • Yuk M. Law, MD

      Affiliations

    • Department of Pediatrics, Doernbecher Children’s Hospital, Oregon Health and Science University, Portland, Oregon
    • Corresponding Author InformationReprint requests: Yuk M. Law, MD, 707 SW Gaines Road, CDRC-P, Oregon Health and Science University, Portland, OR 97239. Telephone: 503-494-9899. Fax: 503-494-2824
    • ,
  • Robert Yim, MD

      Affiliations

    • Department of Pediatrics, Doernbecher Children’s Hospital, Oregon Health and Science University, Portland, Oregon
    • ,
  • Pat Agatisa, PhD

      Affiliations

    • National Childrens Medical Center, George Washington University, Washington, District of Columbia
    • ,
  • Gerard J. Boyle, MD

      Affiliations

    • The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Susan A. Miller, MD

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Kathy Lawrence, MN

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Steven A. Webber, CCHB

      Affiliations

    • Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania

Received 31 May 2005 ,Revised 6 September 2005 ,Accepted 5 October 2005.

References 

  1. Klag MJ , Ford DE , Mead LA , et al.   Serum cholesterol in young men and subsequent cardiovascular disease . N Eng J Med . 1993;328:313–318
  2. Anderson KM , Castelli WP , Levy D . Cholesterol and mortality (30 years of follow-up from the Framingham Study) . JAMA . 1987;257:2176–2180
  3. Law MR , Wald NJ , Thompson SG . By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischemic heart disease? . BMJ . 1994;308:367–373
  4. Cleeman JI , Grundy SM . National Cholesterol Education Program recommendations for cholesterol testing in young adults (a science-based approach) . Circulation . 1997;95:1646–1650
  5. Uzark K , Crowley D , Callow L , Bove E . Hypercholesterolemia after cardiac transplantation in children . Am J Cardiol . 1990;66:1385–1387
  6. Swenson JM , Fricker FJ , Armitage JM . Immunosuppression switch in pediatric heart transplant recipients (cyclosporine to FK 506) . J Am Coll Cardiol . 1995;25:1183–1188
  7. Penson MG , Winter WE , Fricker FJ , et al.   Tacrolimus-based triple-drug immunosuppression minimizes serum lipid elevations in pediatric cardiac transplant recipients . J Heart Lung Transplant . 1999;18:707–713
  8. Chin C , Rosenthal D , Bernstein D . Lipoprotein abnormalities are highly prevalent in pediatric heart transplant recipients . Pediatr Transplant . 2000;4:193–199
  9. Seipelt IM , Crawford SE , Rodgers S , et al.   Hypercholesterolemia is common after pediatric heart transplantation (Initial experience with pravastatin) . J Heart Lung Transplant . 2004;23:317–322
  10. Boucek MM , Novick RJ , Bennett LE , et al.   The registry of the International Society of Heart and Lung Transplantation (second official pediatric report—1998) . J Heart Lung Transplant . 1998;17:1141–1160
  11. Gao SZ , Schroeder JS , Hunt S , Stinson SB . Retransplantation for severe accelerated coronary artery disease in heart transplant recipients . Am J Cardiol . 1988;62:876–881
  12. Eich D , Thompson JA , Ko DJ , et al.   Hypercholesterolemia in long term survivors of heart transplantation (an early marker of accelerated coronary artery disease) . J Heart Lung Transplant . 1991;10:45–49
  13. Sharples LD , Caine N , Mullins P , et al.   Risk factor analysis for the major hazards following heart transplantation—rejection, infection, and coronary occlusive disease . Transplantation . 1991;52:244–252
  14. Valantine H . Role of lipids in allograft vascular disease (a multicenter study of intimal thickening detected by intravascular ultrasound) . J Heart Lung Transplant . 1995;14:S234–S237
  15. Valantine H . Cardiac allograft vasculopathy after heart transplantation (risk factors and management) . J Heart Lung Transplant . 2004;23:S187–S193
  16. Rickenbacher PR , Kemna MS , Pinto FJ , et al.   Coronary artery intimal thickening in the transplanted heart (an in vivo intracoronary ultrasound study of immunologic and metabolic risk factors) . Transplantation . 1996;61:46–53
  17. Keogh A , Simmons L , Spratt P , et al.   Hyperlipidemia after heart transplantation . J Heart Lung Transplant . 1988;7:171–175
  18. Miller LW , Schlant RC , Kobashigawa J , Kubo S , Renlund DG . 24th Bethesda conference: cardiac transplantation. Task Force 5: complications . JAMA . 1993;22:41–54
  19. Klausss V , Konig A , Spes C , et al.   Cyclosporine versus tacrolimus (FK 506) for prevention of cardiac allograft vasculopathy . Am J Cardiol . 2000;85:266–269
  20. Reichart B , Meiser B , Vigano M , et al.   European multi-center tacrolimus (FK 506) heart pilot study (one year results—European Tacrolimus Multicenter Study Group) . J Heart Lung Transplant . 1998;17:775–781
  21. Taylor DO , Barr ML , Radovancevic B , et al.   A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation (decreased hyperlipidemia and hypertension with tacrolimus) . J Heart Lung Transplant . 1999;18:336–345
  22. Cantin B , Kwok B , Shiba N , Valantine HA , Hunt SA , Chan MC . Post-operative conversion from cyclosporine to tacrolimus in heart transplantation (a single-center experience) . J Heart Lung Transplant . 2003;22:723–730
  23. Hickman TB , Briefel RR , Carroll MD , et al.   Distributions and trends of serum lipid levels among United States children and adolescents ages 4–19 years (data from the Third National Health and Nutrition Examination Survey) . Prev Med . 1998;27:879–890
  24. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults . Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) . JAMA . 2001;285:2486–2497
  25. Steinberg D , Gotto AM . Preventing coronary artery disease by lowering cholesterol levels (fifty years from bench to bedside) . JAMA . 1999;282:2043–2050
  26. Li S , Chen W , Srinivasan S , et al.   Childhood cardiovascular risk factors and carotid vascular changes in adulthood (the Bogalusa Heart Study) . JAMA . 2003;290:2271–2276
  27. Raitakari OT , Juonala M , Kähönen M , et al.   Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood (the Cardiovascular Risk in Young Finns Study) . JAMA . 2003;290:2277–2283
  28. McGill HC , McMahan CA , Malcom G , Oalmann MC , Strong JP  PDAY Research Group . Effects of serum lipoproteins and smoking on atherosclerosis in young men and women . Arterioscler Thromb Vasc Biol . 1997;17:95–107
  29. Davis PH , Dawson JD , Riley WA , Lauer RM . Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age (the Muscatine study) . Circulation . 2001;104:2815–2819
  30. Strong JP , Malcom GT , McMahan CA , et al.   Prevalence and extent of atherosclerosis in adolescents and young adults (implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study) . JAMA . 1999;281:727–735
  31. American Academic of Pediatrics. Committee on Nutrition . Cholesterol in childhood . Pediatrics . 1998;101:141–147

PII: S1053-2498(05)00753-9

doi: 10.1016/j.healun.2005.10.006

The Journal of Heart and Lung Transplantation
Volume 25, Issue 3 , Pages 276-282 , March 2006

Article Tools

* Image Usage & Resolution