The Journal of Heart and Lung Transplantation
Volume 25, Issue 3 , Pages 283-288 , March 2006

Rejection With Hemodynamic Compromise: Objective Evidence for Efficacy of Photopheresis

  • J.K. Kirklin, MD

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • Corresponding Author InformationReprint requests: J. K. Kirklin, MD, Department of Surgery, University of Alabama at Birmingham, 739 Zeigler Building, Birmingham, AL 35294. Telephone: 205-934-3368. Fax: 205-934-5261
    • ,
  • R.N. Brown, BS

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • S.T. Huang, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • D.C. Naftel, PhD

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • S.M. Hubbard, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • B.K. Rayburn, RN

      Affiliations

    • Department of Nursing, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • D.C. McGiffin, MD

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • R.B. Bourge, MD

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • R.L. Benza, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • J.A. Tallaj, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • L.J. Pinderski, MD, PhD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • S.V. Pamboukian, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • J.F. George, PhD

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • M. Marques, MD

      Affiliations

    • Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

Received 28 April 2005 ,Revised 21 September 2005 ,Accepted 5 October 2005.

References 

  1. Barr M . Photopheresis for the prevention and treatment of transplant rejection . J Cutan Med Surg . 2003;9:18–19
  2. Barr M , Meiser B , Eisen H , et al.   Photopheresis for the prevention of rejection in cardiac transplantation . N Engl J Med . 1998;339:1744–1751
  3. Kirklin J , Young J , McGriffin D . In: Methodology for clinical research in cardiac transplantation. Heart Transplantation . New York: Churchill Livingstone; 2003;p. 57–104
  4. Michaels P , Espejo M , Kobashigawa J , et al.   Humoral rejection in cardiac transplantation (risk factors, hemodynamic consequences and relationship to transplant coronary artery disease) . J Heart Lung Transplant . 2003;22:58–69
  5. Book W , Kelley L , Gravanis M . Fulminant mixed humoral and cellular rejection in a cardiac transplant recipient (a review of the histologic findings and literature) . J Heart Lung Transplant . 2003;22:604–607
  6. Webber S , Naftel D , Parker J , et al.   Late rejection episodes more than 1 year after pediatric heart transplantation (risk factors and outcomes) . J Heart Lung Transplant . 2003;22:869–875
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  9. Mills RM , Naftel DC , Kirklin JK , et al.   Heart transplant rejection with hemodynamic compromise (a multi-institutional study of the role of endomyocardial cellular infiltrate) . J Heart Lung Transplant . 1997;16:813–821
  10. Pahl E , Naftel DC , Canter CE , et al.   Death after rejection with severe hemodynamic compromise in pediatric heart transplant recipients (a multi-institutional study) . J Heart Lung Transplant . 2001;20:279–287
  11. Edelson R , Berger C , Gasparro F , et al.   Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results . N Engl J Med . 1987;316:297–303
  12. Barr M , Baker C , Schenkel F , et al.   Prophylactic photopheresis and chronic rejection (effects on graft intimal hyperplasia in cardiac transplantation) . Clin Transplant . 2000;14:162–166
  13. Barr M , McLaughlin S , Murphy M , et al.   Prophylactic photopheresis and effect on graft atherosclerosis in cardiac transplantation . Transplant Proc . 1995;27:1993–1994
  14. Girardi M , Schechner J , Glusac E , Berger C , Edelson R . Transimmunization and the evolution of extracorporeal photochemotherapy . Transfus Apher Sci . 2002;26:181–190
  15. Maeda A , Schwartz A , Kernebeck K , et al.   Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells . J Immunol . 2005;174: 5968-76
  16. Liu K , Iyoda T , Saternus M , et al.   Immune tolerance after delivery of dying cells to dendritic cells in situ . J Immunol . 2002;196:1091–1097
  17. Verhoven B , Schlegel R , Williamson P . Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes . J Exp Med . 1995;182:1597–1601
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  19. Ferguson T , Herndon J , Elzey B , et al.   Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness . J Immunol . 2002;168:5589–5595
  20. DeCarvalho Bittencourt M , Perruche S , Contassot E , et al.   Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers . Blood . 2001;98:224–230

PII: S1053-2498(05)00751-5

doi: 10.1016/j.healun.2005.10.004

The Journal of Heart and Lung Transplantation
Volume 25, Issue 3 , Pages 283-288 , March 2006

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