« Previous
Next »
The Journal of Heart and Lung Transplantation
Volume 25, Issue 3
, Pages 302-309
, March 2006
Efficacy of Mycophenolic Acid Combined With KRP-203, a Novel Immunomodulator, in a Rat Heart Transplantation Model
References
- . Optimizing the immunosuppressive regimen in heart transplantation . J Heart Lung Transplant . 2004;23:S207–S213
- . Chronic graft rejection . Curr Opin Immunol . 1994;6:770–776
-
.
Chronic transplant dysfunction and transplant arteriosclerosis
(new insights into underlying mechanisms)
.
Expert Rev Mol Med
. 2003;2003:1–23
- . Molecular targets for existing and novel immunosuppressive drugs . Expert Rev Mol Med . 2000;2000:1–23
- . Nephrotoxicity of immunosuppressive drugs (new insight and preventive strategies) . Curr Opin Crit Care . 2001;7:384–389
- . Chronic cyclosporine nephropathy (the Achilles’ heel of immunosuppressive therapy) . Kidney Int . 1996;50:1089–1100
- . Hypertension after cardiac transplantation (pathophysiology and management) . Curr Opin Nephrol Hypertens . 1995;4:443–451
- . Calcineurin inhibitors and post-transplant hyperlipidaemias . Drug Saf . 2001;24:755–766
- KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts . Circulation . 2005;111:222–229
- A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts . Transplant Proc . 2005;37:143–145
- . The use of mycophenolate mofetil in transplant recipients . Immunopharmacology . 2000;47:215–245
- . Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection . Lancet . 1995;345:1321–1325
- Beneficial effects of conversion from cyclosporin to azathioprine after kidney transplantation . Lancet . 1995;345:610–614
- Simplified method of heterotopic rat heart transplantation using the cuff technique (application to sublethal dose protocol of methotrexate on allograft survival) . Microsurgery . 2001;21:16–21
- The immune modulator FTY720 targets sphingosine 1-phosphate receptors . J Biol Chem . 2002;277:21453–21457
- . Ex vivo blockade of endothelin-1 inhibits graft coronary artery disease in a rodent cardiac allograft model . J Heart Lung Transplant . 2002;21:417–424
- . Inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts . Transplantation . 1999;67:1542–1547
-
.
Crosstalk of endothelin-1 and platelet-derived growth factor in cardiac allograft arteriosclerosis
.
JAMA
. 2002;39:710–717
- . Does transforming growth factor beta 1 play a role in the pathogenesis of chronic allograft rejection? . Transpl Int . 1999;12:393–401
- . Induction of cardiac fibrosis by transforming growth factor-beta(1) . Mol Genet Metab . 2000;71:418–435
- . Macrophages and transplant arteriosclerosis (known and novel molecules) . J Heart Lung Transplant . 1995;14:S111–S115
- The use of (99m) technetium-labeled MCP-1 to assess graft coronary artery disease in rat cardiac allografts . J Heart Lung Transplant . 2002;21:1009–1015
- . E-selectin early overexpression induced by allogeneic activation in isolated mouse lung . Transplantation . 2004;78:1283–1289
- Mycophenolate mofetil prevents transplant arteriosclerosis by direct inhibition of vascular smooth muscle cell proliferation . Transplantation . 2004;77:1661–1667
- Conversion from cyclosporine A to mycophenolate mofetil protects recipient kidney and prevents intimal hyperplasia in rat aortic allografts . Transpl Immunol . 2004;13:219–227
- . Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion . Nephrol Dial Transplant . 1999;14:58–63
- Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells (in vitro study) . Transplant Proc . 2000;32:2026–2027
- . Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts . Transpl Immunol . 1996;4:64–67
- . Mycophenolate mofetil decreases antibody production after cardiac transplantation . J Heart Lung Transplant . 2002;21:282–285
- Three-year results of a randomized, double-blind, controlled trial of mycophenolate mofetil versus azathioprine in cardiac transplant recipients . J Heart Lung Transplant . 2005;24:517–525
- Sustained suppression of peripheral blood immune functions by treatment with mycophenolate mofetil correlates with reduced severity of cardiac allograft rejection . J Heart Lung Transplant . 2004;23:334–351
- Prevention of glomerular crescent formation in glomerulonephritis by mycophenolate mofetil in rats . Nephrol Dial Transplant . 2004;19:2228–2236
- . Mycophenolate mofetil prevents development of urinary protein in autoimmune nephritis . Kidney Int . 2003;64:365–366
- . In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate (mechanistic insights) . Cell Signal . 2005;17:131–139
- . Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5 . Ther Drug Monit . 2004;26:600–608
- First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients . J Am Soc Nephrol . 2002;13:1073–1083
- Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate . J Biol Chem . 2004;279:13839–13848
This study was supported by research grants from the Ministry of Education, Science, Sports and Culture (#16590667 to M.T. and #16590625 to E.K.) and Daiwa Securities Health Foundation (M.T.).
PII: S1053-2498(05)00748-5
doi: 10.1016/j.healun.2005.09.021
© 2006 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
The Journal of Heart and Lung Transplantation
Volume 25, Issue 3
, Pages 302-309
, March 2006
