The Journal of Heart and Lung Transplantation
Volume 24, Issue 10 , Pages 1468-1482 , October 2005

Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part IV: Recipient-Related Risk Factors and Markers

  • Mark L. Barr, MD

      Affiliations

    • University of Southern California, Los Angeles, California
    • Corresponding Author InformationReprint requests: Mark L. Barr, MD, Department of Cardiothoracic Surgery, University of Southern California and Children’s Hospital of Los Angeles, 1520 San Pablo Street, Suite 4300, Los Angeles, CA 90033. Telephone 323-442-5849. Fax: 323-442-5956.
    • ,
  • Steven M. Kawut, MD, MS

      Affiliations

    • Columbia University, New York, New York
    • ,
  • Timothy P. Whelan, MD

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Reda Girgis, MD

      Affiliations

    • Johns Hopkins University, Baltimore, Maryland
    • ,
  • Heidi Böttcher, MD

      Affiliations

    • Deutsches Herzzentrum, Berlin, Germany
    • ,
  • Joshua Sonett, MD

      Affiliations

    • Columbia University, New York, New York
    • ,
  • Wickii Vigneswaran, MD

      Affiliations

    • Loyola University Medical Center, Maywood, Illinois
    • ,
  • David M. Follette, MD

      Affiliations

    • University of California, Sacramento, California
    • ,
  • Paul A. Corris, MB (FRCP)

      Affiliations

    • Freeman Hospital, Newcastle upon Tyne, UK

Received 6 October 2004 ,Revised 7 February 2005 ,Accepted 17 February 2005.

References 

  1. Trulock EP , Edwards LB , Taylor DO , et al.   The registry of the International Society for Heart and Lung Transplantation (twentieth official adult lung and heart–lung transplant report) . J Heart Lung Transplant . 2003;22:625–635
  2. Christie JD , Kotloff RM , Pochettino A , et al.   Clinical risk factors for primary graft failure following lung transplantation . Chest . 2003;124:1232–1241
  3. Chatila WM , Furukawa S , Gaughan JP , Criner GJ . Respiratory failure after lung transplantation . Chest . 2003;123:165–173
  4. Khan SU , Salloum J , O’Donovan PB , et al.   Acute pulmonary edema after lung transplantation (the pulmonary reimplantation response) . Chest . 1999;116:187–194
  5. Fiser SM , Kron IL , McLendon Long S , et al.   Early intervention after severe oxygenation index elevation improves survival following lung transplantation . J Heart Lung Transplant . 2001;20:631–636
  6. Boucek MM , Edwards LB , Keck BM , et al.   The registry of the International Society for Heart and Lung Transplantation (fifth official pediatric report) . J Heart Lung Transplant . 2002;21:827–840
  7. Kanasky WF , Anton SD , Rodrigue JR , et al.   Impact of body weight on long-term survival after lung transplantation . Chest . 2002;121:401–406
  8. Madill J , Gutierrez C , Grossman J , et al.   Nutritional assessment of the lung transplant patient (body mass index as a predictor of 90-day mortality following transplantation) . J Heart Lung Transplant . 2001;20:288–296
  9. Kramer MR , Marshall SE , Tiroke A , et al.   Clinical significance of hyperbilirubinemia in patients with pulmonary hypertension undergoing heart-lung transplantation . J Heart Lung Transplant . 1991;10:317–321
  10. Foreman MG , Mannino DM , Moss M . Cirrhosis as a risk factor for sepsis and death (analysis of the National Hospital Discharge Survey) . Chest . 2003;124:1016–1020
  11. Kawut SM , Horn EM , Berekashvili KK , et al.   New predictors of outcome in idiopathic pulmonary arterial hypertension . Am J Cardiol . 2005;95:199–203
  12. Klima LD , Kowdley KV , Lewis SL , Wood DE , Aitken ML . Successful lung transplantation in spite of cystic fibrosis–associated liver disease (a case series) . J Heart Lung Transplant . 1997;16:934–938
  13. Patel VS , Palmer SM , Messier RH , Davis RD . Clinical outcome after coronary artery revascularization and lung transplantation . Ann Thorac Surg . 2003;75:372–377
  14. Lau CL , Palmer SM , Posther KE , et al.   Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients . Ann Thorac Surg . 2000;69:1520–1524
  15. Scornik JC , Zander DS , Baz MA , Donnelly WH , Staples ED . Susceptibility of lung transplants to preformed donor-specific HLA antibodies as detected by flow cytometry . Transplantation . 1999;68:1542–1546
  16. Yu NC , Haug MT , Khan SU , et al.   Does the donor–recipient ABO blood group compatibility status predict subsequent lung transplantation outcomes? . J Heart Lung Transplant . 1999;18:764–768
  17. Park SJ , Nguyen DQ , Savik K , et al.   Pre-transplant corticosteroid use and outcome in lung transplantation . J Heart Lung Transplant . 2001;20:304–309
  18. Schafers HJ , Wagner TO , Demertzis S , et al.   Preoperative corticosteroids. A contraindication to lung transplantation? . Chest . 1992;102:1522–1525
  19. Brugiere O , Thabut G , Castier Y , et al.   Lung retransplantation for bronchiolitis obliterans syndrome (long-term follow-up in a series of 15 recipients) . Chest . 2003;123:1832–1837
  20. Meyers BF , Lynch JP , Battafarano RJ , et al.   Lung transplantation is warranted for stable, ventilator-dependent recipients . Ann Thorac Surg . 2000;70:1675–1678
  21. Novick RJ , Stitt LW , Al-Kattan K , et al.   Pulmonary retransplantation: predictors of graft function and survival in 230 patients. Pulmonary Retransplant Registry . Ann Thorac Surg . 1998;65:227–234
  22. Dusmet M , Winton TL , Kesten S , Maurer J . Previous intrapleural procedures do not adversely affect lung transplantation . J Heart Lung Transplant . 1996;15:249–254
  23. Hirt SW , Rahimi A , Moller F , Hein M , Bottcher H , Cremer J . Does previous thoracic surgery increase perioperative risk in lung transplantation? . Transplant Proc . 2001;33:3572–3573
  24. Arcasoy SM , Christie JD , Pochettino A , et al.   Characteristics and outcomes of patients with sarcoidosis listed for lung transplantation . Chest . 2001;120:873–880
  25. Hadjiliadis D , Sporn TA , Perfect JR , et al.   Outcome of lung transplantation in patients with mycetomas . Chest . 2002;121:128–134
  26. Vricella LA , Karamichalis JM , Ahmad S , et al.   Lung and heart–lung transplantation in patients with end-stage cystic fibrosis (the Stanford experience) . Ann Thorac Surg . 2002;74:13–17
  27. Wiebe K , Wahlers T , Harringer W , et al.   Lung transplantation for cystic fibrosis–a single center experience over 8 years . Eur J Cardiothorac Surg . 1998;14:191–196
  28. Wisser W , Deviatko E , Simon-Kupilik N , et al.   Lung transplantation following lung volume reduction surgery . J Heart Lung Transplant . 2000;19:480–487
  29. Stoica SC , McNeil KD , Perreas K , et al.   Heart–lung transplantation for Eisenmenger syndrome (early and long-term results) . Ann Thorac Surg . 2001;72:1887–1891
  30. Bridges ND , Mallory GB , Huddleston CB , et al.   Lung transplantation in children and young adults with cardiovascular disease . Ann Thorac Surg . 1995;59:813–820
  31. Baz MA , Palmer SM , Staples ED , et al.   Lung transplantation after long-term mechanical ventilation (results and 1-year follow-up) . Chest . 2001;119:224–227
  32. Flume PA , Egan TM , Westerman JH , et al.   Lung transplantation for mechanically ventilated patients . J Heart Lung Transplant . 1994;13:15–21
  33. Cassivi SD , Meyers BF , Battafarano RJ , et al.   Thirteen-year experience in lung transplantation for emphysema . Ann Thorac Surg . 2002;74:1663–1669
  34. King RC , Binns OA , Rodriguez F , et al.   Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation . Ann Thorac Surg . 2000;69:1681–1685
  35. Egan TM , Detterbeck FC , Mill MR , et al.   Long term results of lung transplantation for cystic fibrosis . Eur J Cardiothorac Surg . 2002;22:602–609
  36. Thabut G , Vinatier I , Stern JB , et al.   Primary graft failure following lung transplantation (predictive factors of mortality) . Chest . 2002;121:1876–1882
  37. Dudek SM , Garcia JG . Cytoskeletal regulation of pulmonary vascular permeability . J Appl Physiol . 2001;91:1487–1500
  38. Halldorsson AO , Kronon MT , Allen BS , Rahman S , Wang T . Lowering reperfusion pressure reduces the injury after pulmonary ischemia . Ann Thorac Surg . 2000;69:198–203
  39. Halldorsson A , Kronon M , Allen BS , et al.   Controlled reperfusion after lung ischemia (implications for improved function after lung transplantation) . J Thorac Cardiovasc Surg . 1998;115:415–424
  40. Clark SC , Sudarshan C , Khanna R , et al.   Controlled reperfusion and pentoxifylline modulate reperfusion injury after single lung transplantation . J Thorac Cardiovasc Surg . 1998;115:1335–1341
  41. Bhabra MS , Hopkinson DN , Shaw TE , Onwu N , Hooper TL . Controlled reperfusion protects lung grafts during a transient early increase in permeability . Ann Thorac Surg . 1998;65:187–192
  42. Pierre AF , DeCampos KN , Liu M , et al.   Rapid reperfusion causes stress failure in ischemic rat lungs . J Thorac Cardiovasc Surg . 1998;116:932–942
  43. Bando K , Keenan RJ , Paradis IL , et al.   Impact of pulmonary hypertension on outcome after single-lung transplantation . Ann Thorac Surg . 1994;58:1336–1342
  44. Chapelier A , Vouhe P , Macchiarini P , et al.   Comparative outcome of heart–lung and lung transplantation for pulmonary hypertension . J Thorac Cardiovasc Surg . 1993;106:299–307
  45. Okada Y , Hoshikawa Y , Ejima Y , et al.   Beta-blocker prevented repeated pulmonary hypertension episodes after bilateral lung transplantation in a patient with primary pulmonary hypertension . J Thorac Cardiovasc Surg . 2004;128:793–794
  46. Franke U , Wiebe K , Harringer W , et al.   Ten years experience with lung and heart–lung transplantation in primary and secondary pulmonary hypertension . Eur J Cardiothorac Surg . 2000;18:447–452
  47. Huerd SS , Hodges TN , Grover FL , et al.   Secondary pulmonary hypertension does not adversely affect outcome after single lung transplantation . J Thorac Cardiovasc Surg . 2000;119:458–465
  48. Dahlberg P, Savik K, Grubbs B, et al. Preoperative pulmonary artery pressure is associated with diminished survival after single lung transplantation for chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg (in press).
  49. Conte JV , Borja MJ , Patel CB , et al.   Lung transplantation for primary and secondary pulmonary hypertension . Ann Thorac Surg . 2001;72:1673–1679
  50. Bando K , Paradis IL , Komatsu K , et al.   Analysis of time-dependent risks for infection, rejection, and death after pulmonary transplantation . J Thorac Cardiovasc Surg . 1995;109:49–57
  51. Bavaria JE , Kotloff R , Palevsky H , et al.   Bilateral versus single lung transplantation for chronic obstructive pulmonary disease . J Thorac Cardiovasc Surg . 1997;113:520–527
  52. Pochettino A , Kotloff RM , Rosengard BR , et al.   Bilateral versus single lung transplantation for chronic obstructive pulmonary disease (intermediate-term results) . Ann Thorac Surg . 2000;70:1813–1818
  53. Szeto WY , Kreisel D , Karakousis GC , et al.   Cardiopulmonary bypass for bilateral sequential lung transplantation in patients with chronic obstructive pulmonary disease without adverse effect on lung function or clinical outcome . J Thorac Cardiovasc Surg . 2002;124:241–249
  54. Sundaresan RS , Shiraishi Y , Trulock EP , et al.   Single or bilateral lung transplantation for emphysema? . J Thorac Cardiovasc Surg . 1996;112:1485–1494
  55. Meyer DM , Bennett LE , Novick RJ , Hosenpud JD . Single vs bilateral, sequential lung transplantation for end-stage emphysema (influence of recipient age on survival and secondary end-points) . J Heart Lung Transplant . 2001;20:935–941
  56. Meyers BF , Lynch JP , Trulock EP , et al.   Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis (a ten-year institutional experience) . J Thorac Cardiovasc Surg . 2000;120:99–107
  57. Wan S , LeClerc JL , Vincent JL . Inflammatory response to cardiopulmonary bypass (mechanisms involved and possible therapeutic strategies) . Chest . 1997;112:676–692
  58. Butler J , Rocker GM , Westaby S . Inflammatory response to cardiopulmonary bypass . Ann Thorac Surg . 1993;55:552–559
  59. Downing SW , Edmunds LH . Release of vasoactive substances during cardiopulmonary bypass . Ann Thorac Surg . 1992;54:1236–1243
  60. Aeba R , Griffith BP , Kormos RL , et al.   Effect of cardiopulmonary bypass on early graft dysfunction in clinical lung transplantation . Ann Thorac Surg . 1994;57:715–722
  61. Sommers KE , Griffith BP , Hardesty RL , Keenan RJ . Early lung allograft function in twin recipients from the same donor (risk factor analysis) . Ann Thorac Surg . 1996;62:784–790
  62. Gammie JS , Cheul Lee J , Pham SM , et al.   Cardiopulmonary bypass is associated with early allograft dysfunction but not death after double-lung transplantation . J Thorac Cardiovasc Surg . 1998;115:990–997
  63. Triantafillou AN , Pasque MK , Huddleston CB , et al.   Predictors, frequency, and indications for cardiopulmonary bypass during lung transplantation in adults . Ann Thorac Surg . 1994;57:1248–1251
  64. de Boer WJ , Hepkema BG , Loef BG , et al.   Survival benefit of cardiopulmonary bypass support in bilateral lung transplantation for emphysema patients . Transplantation . 2002;73:1621–1627
  65. Sheridan BC , Hodges TN , Zamora MR , et al.   Acute and chronic effects of bilateral lung transplantation without cardiopulmonary bypass on the first transplanted lung . Ann Thorac Surg . 1998;66:1755–1758
  66. Rutledge R , Sheldon GF , Collins ML . Massive transfusion . Crit Care Clin . 1986;2:791–805
  67. Pararajasingam R , Nicholson ML , Bell PR , Sayers RD . Non-cardiogenic pulmonary oedema in vascular surgery . Eur J Vasc Endovasc Surg . 1999;17:93–105
  68. Kaiser LR , Pasque MK , Trulock EP , et al.   Bilateral sequential lung transplantation (the procedure of choice for double-lung replacement) . Ann Thorac Surg . 1991;52:438–445
  69. Peterson KL , DeCampli WM , Feeley TW , Starnes VA . Blood loss and transfusion requirements in cystic fibrosis patients undergoing heart–lung or lung transplantation . J Cardiothorac Vasc Anesth . 1995;9:59–62
  70. Jaquiss RD , Huddleston CB , Spray TL . Use of aprotinin in pediatric lung transplantation . J Heart Lung Transplant . 1995;14:302–307
  71. Royston D . Aprotinin therapy in heart and heart–lung transplantation . J Heart Lung Transplant . 1993;12(suppl):S19–S25
  72. Kemkes BM . Hemostatic failures and heart–lung transplantation (assessing the current situation) . J Heart Lung Transplant . 1993;12(suppl):S3–S6
  73. Gu YJ , de Haan J , Brenken UP , et al.  Groningen Lung Transplant Group   Clotting and fibrinolytic disturbance during lung transplantation (effect of low-dose aprotinin) . J Thorac Cardiovasc Surg . 1996;112:599–606
  74. Kesten S , de Hoyas A , Chaparro C , et al.   Aprotinin reduces blood loss in lung transplant recipients . Ann Thorac Surg . 1995;59:877–879
  75. Francalancia NA , Aeba R , Yousem SA , Griffith BP , Marrone GC . Deleterious effects of cardiopulmonary bypass on early graft function after single lung allotransplantation (evaluation of a heparin-coated bypass circuit) . J Heart Lung Transplant . 1994;13:498–507
  76. Detterbeck FC , Egan TM , Mill MR . Lung transplantation after previous thoracic surgical procedures . Ann Thorac Surg . 1995;60:139–143
  77. Shitrit D , Fink G , Sahar G , et al.   Successful lung transplantation following lung volume reduction surgery . Thorac Cardiovasc Surg . 2003;51:274–276
  78. Kawaguchi A , Gandjbakhch I , Pavie A , et al.   Heart and unilateral lung transplantation in patients with end-stage cardiopulmonary disease and previous thoracic operations . J Thorac Cardiovasc Surg . 1989;98:343–349
  79. Reichart B , Gulbins H , Meiser BM , et al.   Improved results after heart-lung transplantation (a 17-year experience) . Transplantation . 2003;75:127–132
  80. Pereszlenyi A , Lang G , Steltzer H , et al.   Bilateral lung transplantation with intra- and postoperatively prolonged ECMO support in patients with pulmonary hypertension . Eur J Cardiothorac Surg . 2002;21:858–863
  81. Webert KE , Blajchman MA . Transfusion-related acute lung injury . Transfus Med Rev . 2003;17:252–262
  82. Popovsky MA , Davenport RD . Transfusion-related acute lung injury (femme fatale?) . Transfusion . 2001;41:312–315
  83. Rizk A , Gorson KC , Kenney L , Weinstein R . Transfusion-related acute lung injury after the infusion of IVIG . Transfusion . 2001;41:264–268
  84. Silliman CC , Voelkel NF , Allard JD , et al.   Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model . J Clin Invest . 1998;101:1458–1467
  85. Dykes A , Smallwood D , Kotsimbos T , Street A . Transfusion-related acute lung injury (TRALI) in a patient with a single lung transplant . Br J Haematol . 2000;109:674–676
  86. Lau CL , Patterson GA . Technical considerations in lung transplantation . Chest Surg Clin N Am . 2003;13:463–483
  87. Leibowitz DW , Smith CR , Michler RE , et al.   Incidence of pulmonary vein complications after lung transplantation (a prospective transesophageal echocardiographic study) . JAMA . 1994;24:671–675
  88. Sarsam MA , Yonan NA , Beton D , McMaster D , Deiraniya AK . Early pulmonary vein thrombosis after single lung transplantation . J Heart Lung Transplant . 1993;12:17–19
  89. Shah AS , Michler RE , Downey RJ , et al.   Management strategies for pulmonary vein thrombosis following single lung transplantation . J Card Surg . 1995;10:169–178
  90. Malden ES , Kaiser LR , Gutierrez FR . Pulmonary vein obstruction following single lung transplantation . Chest . 1992;102:645–647
  91. Schulman LL , Anandarangam T , Leibowitz DW , et al.   Four-year prospective study of pulmonary venous thrombosis after lung transplantation . J Am Soc Echocardiogr . 2001;14:806–812
  92. Griffith BP , Magee MJ , Gonzalez IF , et al.   Anastomotic pitfalls in lung transplantation . J Thorac Cardiovasc Surg . 1994;107:743–753
  93. Clark SC , Levine AJ , Hasan A , et al.   Vascular complications of lung transplantation . Ann Thorac Surg . 1996;61:1079–1082
  94. Casula RP , Stoica SC , Wallwork J , Dunning J . Pulmonary vein augmentation for single lung transplantation . Ann Thorac Surg . 2001;71:1373–1374
  95. Hearne SE , O’Laughlin MP , Davis RD , et al.   Total pulmonary artery occlusion immediately after lung transplantation (successful revascularization with intravascular stents) . J Heart Lung Transplant . 1996;15:532–535
  96. Robert JH , Murith N , de Perrot M , et al.   Lung transplantation (how to perform the venous anastomosis when clamping is too distal) . Ann Thorac Surg . 2000;70:2164–2165
  97. Hausmann D , Daniel WG , Mugge A , et al.   Imaging of pulmonary artery and vein anastomoses by transesophageal echocardiography after lung transplantation . Circulation . 1992;86(suppl):II-251–II-258
  98. Bousamra M , Mewissen MW , Batter J , et al.   Pulmonary artery thrombolysis and stenting after a bilateral sequential lung transplantation . J Heart Lung Transplant . 1997;16:678–680
  99. Gaubert JY , Moulin G , Thomas P , et al.   Anastomotic stenosis of the left pulmonary artery after lung transplantation (treatment by percutaneous placement of an endoprosthesis) . Am J Roentgenol . 1993;161:947–949
  100. Michel-Cherqui M , Brusset A , Liu N , et al.   Intraoperative transesophageal echocardiographic assessment of vascular anastomoses in lung transplantation. A report on 18 cases . Chest . 1997;111:1229–1235
  101. Collins J , Kuhlman JE , Love RB . Acute, life-threatening complications of lung transplantation . Radiographics . 1998;18:21–43
  102. Grazia TJ , Hodges TN , Cleveland JC , Sheridan BC , Zamora MR . Lobar torsion complicating bilateral lung transplantation . J Heart Lung Transplant . 2003;22:102–106
  103. Gilkeson RC , Lange P , Kirby TJ . Lung torsion after lung transplantation (evaluation with helical CT) . Am J Roentgenol . 2000;174:1341–1343
  104. Shen AC , Jennings RB . Kinetics of calcium accumulation in acute myocardial ischemic injury . Am J Pathol . 1972;67:441–452
  105. Collard CD , Lekowski R , Jordan JE , Agah A , Stahl GL . Complement activation following oxidative stress . Mol Immunol . 1999;36:941–948
  106. Novick RJ , Gehman KE , Ali IS , Lee J . Lung preservation (the importance of endothelial and alveolar type II cell integrity) . Ann Thorac Surg . 1996;62:302–314
  107. Follette DM , Fey KH , Livesay JJ , et al.   Citrate reperfusion of ischemic heart in cardiopulmonary bypass . Surg Forum . 1976;27:244–246
  108. Allen BS , Okamoto F , Buckberg GD , et al.   Immediate functional recovery after six hours of regional ischemia by careful control of conditions of reperfusion and composition of reperfusate . J Thorac Cardiovasc Surg . 1986;92:621–635
  109. Rezkalla SH , Kloner RA . No-reflow phenomenon . Circulation . 2002;105:656–662
  110. Carden D , Xiao F , Moak C , et al.   Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins . Am J Physiol . 1998;275:H385–H392
  111. Ross SD , Tribble CG , Gaughen JR , et al.   Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation . Ann Thorac Surg . 1999;67:1428–1433
  112. Bhabra MS , Hopkinson DN , Shaw TE , Hooper TL . Critical importance of the first 10 minutes of lung graft reperfusion after hypothermic storage . Ann Thorac Surg . 1996;61:1631–1635
  113. Ardehali A , Laks H , Russell H , et al.   Modified reperfusion and ischemia–reperfusion injury in human lung transplantation . J Thorac Cardiovasc Surg . 2003;126:1929–1934
  114. Schnickel GT, Ross DJ, Beygui R, et al. Modified reperfusion in clinical lung transplantation: the result of 100 consecutive cases. J Thorac Cardiovasc Surg (in press).
  115. Kron IL , Tribble CG , Kern JA , et al.   Successful transplantation of marginally acceptable thoracic organs . Ann Surg . 1993;217:518–522
  116. Sundaresan S , Semenkovich J , Ochoa L , et al.   Successful outcome of lung transplantation is not compromised by the use of marginal donor lungs . J Thorac Cardiovasc Surg . 1995;109:1075–1079
  117. Pierre AF , Sekine Y , Hutcheon MA , Waddell TK , Keshavjee SH . Marginal donor lungs (a reassessment) . J Thorac Cardiovasc Surg . 2002;123:421–427
  118. Fisher AJ , Donnelly SC , Hirani N , et al.   Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation . Am J Respir Crit Care Med . 2001;163:259–265
  119. Minamiya Y , Tozawa K , Kitamura M , Saito S , Ogawa J . Platelet-activating factor mediates intercellular adhesion molecule-1-dependent radical production in the nonhypoxic ischemia rat lung . Am J Respir Cell Mol Biol . 1998;19:150–157
  120. Moore TM , Khimenko P , Adkins WK , Miyasaka M , Taylor AE . Adhesion molecules contribute to ischemia and reperfusion-induced injury in the isolated rat lung . J Appl Physiol . 1995;78:2245–2252
  121. Naka Y , Toda K , Kayano K , Oz MC , Pinsky DJ . Failure to express the P-selectin gene or P-selectin blockade confers early pulmonary protection after lung ischemia or transplantation . Proc Natl Acad Sci USA . 1997;94:757–761
  122. Kapelanski DP , Iguchi A , Niles SD , Mao HZ . Lung reperfusion injury is reduced by inhibiting a CD18-dependent mechanism . J Heart Lung Transplant . 1993;12:294–306
  123. DeMeester SR , Molinari MA , Shiraishi T , et al.   Attenuation of rat lung isograft reperfusion injury with a combination of anti-ICAM-1 and anti-beta2 integrin monoclonal antibodies . Transplantation . 1996;62:1477–1485
  124. Steinberg JB , Mao HZ , Niles SD , Jutila MA , Kapelanski DP . Survival in lung reperfusion injury is improved by an antibody that binds and inhibits L- and E-selectin . J Heart Lung Transplant . 1994;13:306–318
  125. Rose F , Hattar K , Gakisch S , et al.   Increased neutrophil mediator release in patients with pulmonary hypertension-suppression by inhaled iloprost . Thromb Haemost . 2003;90:1141–1149
  126. Colombat M , Castier Y , Leseche G , et al.   Early expression of adhesion molecules after lung transplantation (evidence for a role of aggregated P-selectin-positive platelets in human primary graft failure) . J Heart Lung Transplant . 2004;23:1087–1092
  127. Sakamaki F , Ishizaka A , Handa M , et al.   Soluble form of P-selectin in plasma is elevated in acute lung injury . Am J Respir Crit Care Med . 1995;151:1821–1826
  128. Sakamaki F , Kyotani S , Nagaya N , et al.   Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy . Circulation . 2000;102:2720–2725
  129. Compeau CG , Ma J , DeCampos KN , et al.   In situ ischemia and hypoxia enhance alveolar macrophage tissue factor expression . Am J Respir Cell Mol Biol . 1994;11:446–455
  130. Salvatierra A , Velasco F , Rodriguez M , et al.   C1-esterase inhibitor prevents early pulmonary dysfunction after lung transplantation in the dog . Am J Respir Crit Care Med . 1997;155:1147–1154
  131. Struber M , Hagl C , Hirt SW , et al.   C1-esterase inhibitor in graft failure after lung transplantation . Intensive Care Med . 1999;25:1315–1318
  132. Serrick C , Adoumie R , Giaid A , Shennib H . The early release of interleukin-2, tumor necrosis factor-alpha and interferon-gamma after ischemia reperfusion injury in the lung allograft . Transplantation . 1994;58:1158–1162
  133. Sekido N , Mukaida N , Harada A , et al.   Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8 . Nature . 1993;365:654–657
  134. Kim DK , Fukuda T , Thompson BT , et al.   Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome . Am J Physiol . 1995;269:L109–L118
  135. Ishikawa H , Takeyoshi I , Aiba M , et al.   The effective dose of FR167653 in pulmonary ischemia–reperfusion injury . Int J Surg Invest . 2000;2:243–252
  136. Pham SM , Yoshida Y , Aeba R , et al.   Interleukin-6, a marker of preservation injury in clinical lung transplantation . J Heart Lung Transplant . 1992;11:1017–1024
  137. Raychaudhuri B , Bonfield TL , Malur A , et al.   Circulating monocytes from patients with primary pulmonary hypertension are hyporesponsive . Clin Immunol . 2002;104:191–198
  138. Humbert M , Monti G , Brenot F , et al.   Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension . Am J Respir Crit Care Med . 1995;151:1628–1631
  139. Koike K , Yamamoto Y , Hori Y , Ono T . Group IIA phospholipase A2 mediates lung injury in intestinal ischemia–reperfusion . Ann Surg . 2000;232:90–97
  140. Corcoran PC , Wang Y , Katz NM , et al.   Platelet activating factor antagonist enhances lung preservation in a canine model of single lung allotransplantation . J Thorac Cardiovasc Surg . 1992;104:66–72
  141. Kawahara K , Tagawa T , Takahashi T , et al.   The effect of the platelet-activating factor inhibitor TCV-309 on reperfusion injury in a canine model of ischemic lung . Transplantation . 1993;55:1438–1439
  142. Su M , Chi EY , Bishop MJ , Henderson WR . Lung mast cells increase in number and degranulate during pulmonary artery occlusion/reperfusion injury in dogs . Am Rev Respir Dis . 1993;147:448–456
  143. Shimizu N , Kita T , Aoe M , et al.   Changes in levels of arachidonic acid metabolites in blood and bronchoalveolar lavage fluid after warm ischemia–reperfusion of lung . Acta Med Okayama . 1991;45:417–422
  144. Naka Y , Marsh HC , Scesney SM , Oz MC , Pinsky DJ . Complement activation as a cause for primary graft failure in an isogeneic rat model of hypothermic lung preservation and transplantation . Transplantation . 1997;64:1248–1255
  145. Bishop MJ , Giclas PC , Guidotti SM , Su ML , Chi EY . Complement activation is a secondary rather than a causative factor in rabbit pulmonary artery ischemia/reperfusion injury . Am Rev Respir Dis . 1991;143:386–390
  146. Pierre AF , Xavier AM , Liu M , et al.   Effect of complement inhibition with soluble complement receptor 1 on pig allotransplant lung function . Transplantation . 1998;66:723–732
  147. Schmid RA , Zollinger A , Singer T , et al.   Effect of soluble complement receptor type 1 on reperfusion edema and neutrophil migration after lung allotransplantation in swine . J Thorac Cardiovasc Surg . 1998;116:90–97
  148. Taghavi S , Abraham D , Riml P , et al.   Co-expression of endothelin-1 and vascular endothelial growth factor mediates increased vascular permeability in lung grafts before reperfusion . J Heart Lung Transplant . 2002;21:600–603
  149. Shennib H , Serrick C , Saleh D , et al.   Alterations in bronchoalveolar lavage and plasma endothelin-1 levels early after lung transplantation . Transplantation . 1995;59:994–998
  150. Giaid A , Yanagisawa M , Langleben D , et al.   Expression of endothelin-1 in the lungs of patients with pulmonary hypertension . N Engl J Med . 1993;328:1732–1739
  151. Mizutani H , Minamoto K , Aoe M , et al.   Expression of endothelin-1 and effects of an endothelin receptor antagonist, TAK-044, at reperfusion after cold preservation in a canine lung transplantation model . J Heart Lung Transplant . 1998;17:835–845
  152. Zwacka RM , Zhang Y , Halldorson J , et al.   CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver . J Clin Invest . 1997;100:279–289
  153. Eppinger MJ , Jones ML , Deeb GM , Bolling SF , Ward PA . Pattern of injury and the role of neutrophils in reperfusion injury of rat lung . J Surg Res . 1995;58:713–718
  154. Fiser SM , Tribble CG , Long SM , et al.   Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response . J Thorac Cardiovasc Surg . 2001;121:1069–1075
  155. Eppinger MJ , Deeb GM , Bolling SF , Ward PA . Mediators of ischemia–reperfusion injury of rat lung . Am J Pathol . 1997;150:1773–1784
  156. Le Moine O , Louis H , Demols A , et al.   Cold liver ischemia–reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in mice . Hepatology . 2000;31:1266–1274
  157. Burne MJ , Daniels F , El Ghandour A , et al.   Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure . J Clin Invest . 2001;108:1283–1290
  158. Deeb GM , Grum CM , Lynch MJ , et al.   Neutrophils are not necessary for induction of ischemia–reperfusion lung injury . J Appl Physiol . 1990;68:374–381
  159. Steimle CN , Guynn TP , Morganroth ML , et al.   Neutrophils are not necessary for ischemia–reperfusion lung injury . Ann Thorac Surg . 1992;53:64–72
  160. Pietropaoli AP , Perkins PT , Perillo IB , Hyde RW . Exhaled nitric oxide does not provide a marker of vascular endothelial function in healthy humans . Am J Respir Crit Care Med . 2000;161:2113–2114
  161. Marczin N , Riedel B , Royston D , Yacoub M . Intravenous nitrate vasodilators and exhaled nitric oxide . Lancet . 1997;349:1742
  162. Marczin N , Riedel B , Royston D , Yacoub M . Exhaled nitric oxide and pulmonary response to iloprost in systemic sclerosis . Lancet . 1998;352:405–406
  163. Marczin N , Riedel B , Gal J , Polak J , Yacoub M . Exhaled nitric oxide during lung transplantation . Lancet . 1997;350:1681–1682

PII: S1053-2498(05)00136-1

doi: 10.1016/j.healun.2005.02.019

The Journal of Heart and Lung Transplantation
Volume 24, Issue 10 , Pages 1468-1482 , October 2005

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