The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 716-722 , June 2004

Risk factors for primary graft failure after pediatric cardiac transplantation: importance of recipient and donor characteristics

  • Jennifer Huang, MD

      Affiliations

    • Division of Pediatric Cardiology, Department of Pediatrics, Washington University, St. Louis, Missouri, USA
    • ,
  • Kim Trinkaus, PhD

      Affiliations

    • Department of Biostatistics, Washington University, St. Louis, Missouri, USA
    • ,
  • Charles B. Huddleston, MD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Washington University, St. Louis, Missouri, USA
    • ,
  • Eric N. Mendeloff, MD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Washington University, St. Louis, Missouri, USA
    • ,
  • Thomas L. Spray, MD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    • ,
  • Charles E. Canter, MD

      Affiliations

    • Division of Pediatric Cardiology, Department of Pediatrics, Washington University, St. Louis, Missouri, USA
    • Corresponding Author InformationReprint requests: Charles E. Canter, MD, Division of Pediatric Cardiology, Department of Pediatrics, Washington University, 1 Children's Place, St. Louis, MO 63110, USA. Telephone: 314-454-6095. Fax: 314-454-2561.

Received 9 January 2003 ,Revised 4 June 2003 ,Accepted 2 August 2003.

References 

  1. Boucek MM, Edwards LB, Keck BM, et al.  The registry of the International Society for Heart and Lung Transplantation (Fifth official pediatric report—2001 to 2002). J Heart Lung Transplant. 2002;21:827–840
  2. Shaddy RE, Naftel DC, Kirklin JK, et al.  Outcome of cardiac transplantation in children. Survival in a contemporary multi-institutional experience. Circulation. 1996;94(suppl II):II.69, II.73
  3. Canter C, Naftel D, Caldwell R, et al.  Survival and risk factors for death after cardiac transplantation in infants. A multi-institutional study. Circulation. 1997;96:227–231
  4. Hauptman PJ, Aranki S, Mudge GH, et al.  Early cardiac allograft failure after orthotopic heart transplantation. Am Heart J. 1994;127:179–186
  5. Dec GW. Heart failure after cardiac transplantation: diagnostic evaluation and treatment options. Am Coll Cardiol Curr J Rev 2002;11:61–6.
  6. Stobierska-Dzierzek B, Awad H, Michler RE. The evolving management of acute right-sided heart failure in cardiac transplant recipients. J Am Coll Cardiol. 2001;38:923–931
  7. Chemmalakuzhy J, Costanzo MR, Meyer P, et al.  Hypotension, acidosis, and vasodilation syndrome post–heart transplant (Prognostic variables and outcomes). J Heart Lung Transplant. 2001;20:1075–1083
  8. Slater JP, Amirhamzeh MMR, Yano OJ, et al.  Discriminating between preservation and reperfusion injury in human cardiac allografts using heart weight and left ventricular mass. Circulation. 1995;92(suppl II):II.223, II.227
  9. Young JB, Hauptman PJ, Naftel DC, et al.  Determinants of early graft failure following cardiac transplantation, a 10-year, multi-institutional, multivariable analysis. J Heart Lung Transplant. 2001;19:212
  10. Kirshbom PM, Bridges ND, Myung RJ, et al.  Use of extracoporeal membrane oxygenation in pediatric thoracic organ transplantation. J Thorac Cardiovasc Surg. 2002;123:130–136
  11. Hsu DT, Quaegebeur JM, Michler RE, et al.  Heart transplantation in children with congenital heart disease. J Am Coll Cardiol. 1995;36:743–749
  12. Chugh R, Marelli D, Child JS, et al.  Heart transplantation in adolescents and adults with congenital heart disease. J Am Coll Cardiol. 2002;39:401A
  13. Kristof AS, Magder S. Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass. Crit Care Med. 1999;27:1121–1127
  14. Argenziano M, Choudhri AF, Oz MC, et al.  A prospective randomized trial of arginine vasopressin in the treatment of vasodilatory shock after left ventricular assist device placement. Circulation. 1997;96(suppl 2):II.286, II.290
  15. del Nido PJ, Armitage JM, Fricker FJ, et al.  Extracorporeal membrane oxygenation support as a bridge to pediatric heart transplantation. Circulation. 1994;90(suppl 2):II.66, II.69
  16. Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med. 2001;345:588–595
  17. Fukushima N, Gundry SR, Razzouk AJ, et al.  Risk factors for graft failure associated with pulmonary hypertension after pediatric heart transplantation. J Thorac Cardiovasc Surg. 1994;107:985–989
  18. Bando K, Konishi H, Kornatsu K, et al.  Improved survival following pediatric cardiac transplantation in high-risk patients. Circulation. 1995;88:218–223
  19. Addonizio LJ, Gerswony WM, Robbins RC, et al.  Elevated pulmonary vascular resistance and cardiac transplantation. Circulation. 1987;76(suppl V):V52–V55
  20. Gajarski RJ, Towbin JA, Bricker JT, et al.  Intermediate follow-up of pediatric heart transplant recipients with elevated pulmonary vascular resistance index. J Am Coll Cardiol. 1994;23:1682–1687
  21. Zales VR, Pahl E, Backer CL, et al.  Pharmacologic reduction of pretransplantation pulmonary vascular resistance predicts outcome after pediatric heart transplantation. J Heart Lung Transplant. 1993;12:965–973
  22. Shaddy RE. Pulmonary hypertension in pediatric heart transplantation. ProgPediatr Cardiol. 2000;11:131–136
  23. Bailey LL, Gundry SR, Razzouk AJ, et al.  Bless the babies (One hundred fifteen late survivors of heart transplantation during the first year of life). J Thorac Cardiovasc Surg. 1993;105:605–615
  24. Baldwin JC, Anderson JL, Boucek MM, et al.  Task Force 2 (Donor guidelines). J Am Coll Cardiol. 1993;22:15–20
  25. Scheule AM, Zimmerman GJ, Johnston JK, et al.  Duration of graft cold ischemia does not affect outcomes in pediatric heart transplant recipients. Circulation. 2002;106(suppl I):I.163, I.167
  26. Fullerton DA, Gundry SR, de Begona JA, et al.  The effects of donor–recipient size disparity in infant and pediatric heart transplantation. J Thorac Cardiovasc Surg. 1992;104:1314–1319
  27. De Begona JA, Gundry SR, Razzouk AJ, et al.  Transplantation of heart after arrest and resuscitation. J Thorac Cardiovasc Surg. 1993;106:1196–1201
  28. Bourge RC, Naftel DC, Costanzo-Nordin MR, et al.  Pretransplantation risk factors for death after heart transplantation (A multiinstitutional study). J Heart Lung Transplant. 1993;12:549–562
  29. Tamisier D, Vouhe P, Le Bidois J, et al.  Donor–recipient size matching in pediatric heart transplantation (A word of caution about small grafts). J Heart Lung Transplant. 1996;15:190–195
  30. Reichert B. Size matching in heart transplantation. J Heart Lung Transplant. 1992;11(suppl):199–202
  31. Constanzo-Nordin MR, Liao Y, Grusk BB, et al.  Oversizing of donor hearts (Beneficial or detrimental?). J Heart Lung Transplant. 1991;10:717–730
  32. Tweddell JS, Canter CE, Bridges ND, et al.  Predictors of operative mortality and morbidity after infant heart transplantation. Ann Thorac Surg. 1994;58:972–977
  33. Grant JW, Canter CE, Spray TL, et al.  Elevated donor cardiac troponin I. A marker of acute graft failure in infant heart recipients. Circulation. 1994;90:2618–2621
  34. Young JB, Naftel DC, Bourge RC, et al.  Matching the heart donor and heart transplant recipient. Clues for successful expansion of the donor pool (A multivariable, multiinstitutional report). J Heart Lung Transplant. 1994;13:353–365

PII: S1053-2498(03)00353-X

doi: 10.1016/j.healun.2003.08.001

The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 716-722 , June 2004

Article Tools