Bronchial artery revascularization restores peribronchial tissue oxygenation after lung transplantation

Kamler, Markus; Nowak, Kai; Bock, Matthias; Herold, Ulf; Motsch, Johann; Hagl, Siegfried; Gebhard, MarthaMaria; Jakob, Heinz

doi:10.1016/j.healun.2003.07.016

« Previous Next »The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 763-766, June 2004

Bronchial artery revascularization restores peribronchial tissue oxygenation after lung transplantation☆

Markus Kamler, MD
- Department of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany
- Reprint requests: Markus Kamler, Department of Thoracic and Cardiovascular Surgery, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany. Telephone: 49-201-723-4904. Fax: 49-201-723-5451.
Kai Nowak, MD
- Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Matthias Bock, MD
- Department of Experimental Surgery, University of Heidelberg, Heidelberg, Germany
Ulf Herold, MD
- Department of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany
Johann Motsch, MD
- Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany
Siegfried Hagl, MD
- Bozen Hospital, Bozen, Italy
MarthaMaria Gebhard, MD
- Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Heinz Jakob, MD
- Department of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany

Received 7 January 2003; received in revised form 22 May 2003; accepted 21 July 2003.

Abstract

With the interruption of the bronchial arteries after lung transplantation, nutritive support is dependent on collateral flow by the pulmonary arteries with desaturated venous blood. Consequently, oxygen deficiency of the peribronchial and dependent lung tissue may occur. Using a canine model for left lung transplantation, we investigated hypoxic peribronchial tissue after conventional lung transplantation and demonstrated restitution of tissue oxygenation after transplantation with bronchial artery revascularization (BAR) (BAR group: Po₂ 120.4 ± 28.7 mm Hg; control group Po₂ 6.8 ± 2.8; p < 0.001). BAR in lung transplantation protects peribronchial tissue of the transplanted graft from hypoxia in the early phase after reperfusion.