Bronchial artery revascularization restores peribronchial tissue oxygenation after lung transplantation☆
Received 7 January 2003; received in revised form 22 May 2003; accepted 21 July 2003.
Abstract
With the interruption of the bronchial arteries after lung transplantation, nutritive support is dependent on collateral flow by the pulmonary arteries with desaturated venous blood. Consequently, oxygen deficiency of the peribronchial and dependent lung tissue may occur. Using a canine model for left lung transplantation, we investigated hypoxic peribronchial tissue after conventional lung transplantation and demonstrated restitution of tissue oxygenation after transplantation with bronchial artery revascularization (BAR) (BAR group: Po2 120.4 ± 28.7 mm Hg; control group Po2 6.8 ± 2.8; p < 0.001). BAR in lung transplantation protects peribronchial tissue of the transplanted graft from hypoxia in the early phase after reperfusion.
aDepartment of Thoracic and Cardiovascular Surgery, University of Essen, Essen, Germany
bDepartment of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
cDepartment of Experimental Surgery, University of Heidelberg, Heidelberg, Germany
dDepartment of Anaesthesiology, University of Heidelberg, Heidelberg, Germany
Reprint requests: Markus Kamler, Department of Thoracic and Cardiovascular Surgery, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany. Telephone: 49-201-723-4904. Fax: 49-201-723-5451.
☆ Supported by the Forschungsschwerpunkt Transplantation of the University of Heidelberg.
ABSTRACT