The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 709-715 , June 2004

Role of mast cells and their mediators in failing myocardium under mechanical ventricular support

  • Ahmet Akgul, MD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
  • ,
  • Christian A Skrabal, MD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
  • ,
  • Larry O Thompson, MD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
  • ,
  • Matthias Loebe, MD, PhD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
  • ,
  • Javier A Lafuente, MD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
  • ,
  • George P Noon, MD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
  • ,
  • Keith A Youker, PhD

      Affiliations

    • Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    • Corresponding Author InformationReprint requests: Keith A. Youker, PhD, Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Telephone: 713-798-4188. Fax: 713-796-0015.

Received 17 December 2002 ,Revised 6 June 2003 ,Accepted 12 June 2003.

References 

  1. Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D. Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. Circulation. 1995;91:2717–2720
  2. Mann DL, Willerson JT. Left ventricular assist devices and the failing heart (A bridge to recovery, a permanent assist device, or a bridge too far?). Circulation. 1998;98:2367–2369
  3. Muller J, Wallukat G, Weng YG, et al.  Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation. 1997;96:542–549
  4. Bruckner BA, Stetson SJ, Perez-Verdia A, et al.  Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant. 2001;20:457–464
  5. Artuc M, Hermes B, Steckelings UM, Grutzkau A, Henz BM. Mast cells and their mediators in cutaneous wound healing—active participants or innocent bystanders?. Exp Dermatol. 1999;8:1–16
  6. Bairoch A, Apweiler R. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res. 2000;28:45–48
  7. Irani AA, Schechter NM, Craig SS, DeBlois G, Schwartz LB. Two types of human mast cells that have distinct neutral protease compositions. Proc Natl Acad Sci U.S.A. 1986;83:4464–4468
  8. Irani AM, Schwartz LB. Human mast cell heterogeneity. Allergy Proc. 1994;15:303–308
  9. de Almeida A, Mustin D, Forman MF, Brower GL, Janicki JS, Carver W. Effects of mast cells on the behavior of isolated heart fibroblasts (Modulation of collagen remodeling and gene expression). J Cell Physiol. 2002;191:51–59
  10. Gruber BL, Kew RR, Jelaska A, et al.  Human mast cells activate fibroblasts (Tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis). J Immunol. 1997;158:2310–2317
  11. Brower GL, Chancey AL, Thanigaraj S, Matsubara BB, Janicki JS. Cause and effect relationship between myocardial mast cell number and matrix metalloproteinase activity. Am J Physiol Heart Circ Physiol. 2002;283:H518–H525
  12. Kofford MW, Schwartz LB, Schechter NM, Yager DR, Diegelmann RF, Graham MF. Cleavage of type I procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide. J Biol Chem. 1997;272:7127–7131
  13. Walgenbach KJ, Gorospe JR, Gratas C, Brunagel G, Hoffman EP, Shestak KC. A Potential Role for Mast Cells in the of bFGF From Normal Myocytes During Angiogenesis In Vivo. J Invest Surg. 2002;15:153–162
  14. Patella V, Marino I, Arbustini E, et al.  Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation. 1998;97:971–978
  15. Swan HJ. Left ventricular dysfunction in ischemic heart disease (Fundamental importance of the fibrous matrix). Cardiovasc Drugs Ther. 1994;8(Suppl 2):305–312
  16. Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83:1849–1865
  17. Bruckner BA, Stetson SJ, Farmer JA, et al.  The implications for cardiac recovery of left ventricular support on myocardial collagen content. Am J Surg. 2000;180:498–501
  18. Galli SJ. New concepts about the mast cell. N Engl J Med. 1993;328:257–265
  19. Artuc M, Steckelings UM, Henz BM. Mast cell-fibroblast interactions (Human mast cells as source and inducers of fibroblast and epithelial growth factors). J Invest Dermatol. 2002;118:391–395
  20. Kondo S, Kagami S, Kido H, Strutz F, Muller GA, Kuroda Y. Role of mast cell tryptase in renal interstitial fibrosis. J Am Soc Nephrol. 2001;12:1668–1676
  21. Caughey GH. Serine proteinases of mast cell and leukocyte granules. A league of their own. Am J Respir Crit Care Med. 1994;150:S138–S142
  22. Welle M. Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J Leukoc Biol. 1997;61:233–245
  23. Caughey GH, Raymond WW, Wolters PJ. Angiotensin II generation by mast cell alpha- and beta- chymases. Biochim Biophys Acta. 2000;1480:245–257
  24. Chandrasekharan UM, Sanker S, Glynias MJ, Karnik SS, Husain A. Angiotensin II-forming activity in a reconstructed ancestral chymase. Science. 1996;271:502–505
  25. Bernasconi P, Di Blasi C, Mora M, et al.  Transforming growth factor-beta 1 and fibrosis in congenital muscular dystrophies. Neuromuscul Disord. 1999;9:28–33
  26. Saarinen J, Kalkkinen N, Welgus HG, Kovanen PT. Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. J Biol Chem. 1994;269:18134–18140
  27. Frank BT, Rossall JC, Caughey GH, Fang KC. Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase. J Immunol. 2001;166:2783–2792
  28. Qu Z, Liebler JM, Powers MR, et al.  Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Am J Pathol. 1995;147:564–573
  29. Sciler G, Welle M, Busato A, Lin S, Gaschen F. Mast cell proliferation and alterations in bFGF amount and localization are involved in the response of muscle to dystrophin deficiency in hypertrophic feline dystrophy. Neuromuscul Disord. 2001;11:56–71
  30. Craig SS, Schechter NM, Schwartz LB. Ultrastructural analysis of maturing human T and TC mast cells in situ. Lab Invest. 1989;60:147–157
  31. Goldstein SM, Leong J, Schwartz LB, Cooke D. Protease composition of exocytosed human skin mast cell protease-proteoglycan complexes. Tryptase resides in a complex distinct from chymase and carboxypeptidase. J Immunol. 1992;148:2475–2482
  32. Hetzer R, Muller JH, Weng Y, Meyer R, Dandel M. Bridging-to-recovery. Ann Thorac Surg. 2001;71:S109–S113
  33. Hetzer R, Muller JH, Weng YG, Loebe M, Wallukat G. Midterm follow-up of patients who underwent removal of a left ventricular assist device after cardiac recovery from end-stage dilated cardiomyopathy. J Thorac Cardiovasc Surg. 2000;120:843–853
  34. Loebe M, Hennig E, Muller J, Spiegelsberger S, Weng Y, Hetzer R. Long-term mechanical circulatory support as a bridge to transplantation, for recovery from cardiomyopathy, and for permanent replacement. Eur J Cardiothorac Surg. 1997;11(Suppl):S18–S24
  35. Scheinin SA, Capek P, Radovancevic B, Duncan JM, McAllister HA, Frazier OH. The effect of prolonged left ventricular support on myocardial histopathology in patients with end-stage cardiomyopathy. ASAIO J. 1992;38:M271–M274

 Supported by the George P. Noon Research Fund, the Turkish Ministry of Health and the German Research Foundation (DFG).

PII: S1053-2498(03)00350-4

doi: 10.1016/j.healun.2003.06.006

The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 709-715 , June 2004