The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 696-700 , June 2004

Effect of the TNF-α–promoter polymorphism on cardiac allograft rejection

  • Maninder Bedi, MD

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Lisa A Postava, MBA

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Srinivas Murali, MD

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Guy A MacGowan, MD

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Michael Mathier, MD

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Lawrence Shears, MD

      Affiliations

    • Division of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Robert Kormos, MD

      Affiliations

    • Division of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Richard Holubkov, PhD

      Affiliations

    • Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA
    • ,
  • Barry London, MD, PhD

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • ,
  • Dennis M McNamara, MD

      Affiliations

    • Cardiovascular Institute , University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    • Corresponding Author InformationReprint requests: Dennis M. McNamara, MD, Heart Failure Section, University of Pittsburgh, 200 Lothrop Street, S-558 Scaife Hall, Pittsburgh, Pennsylvania 15213-2582, USA. Telephone: 412-647-2703. Fax: 412-647-0595.

Received 2 December 2002 ,Revised 20 June 2003 ,Accepted 27 July 2003.

References 

  1. Chollet-Martin S, Depoix JP, Hvass U, et al.  Raised plasma levels of tumor necrosis factor in heart allograft rejection. Transplant Proc. 1990;22:283–286
  2. Arbustini E, Grasso M, Diegoli M, et al.  Expression of tumor necrosis factor in human acute cardiac rejection. An Immunohistochemical and immunoblotting study. Am J Pathol. 1991;139:709–715
  3. Alvarez CM, Fernandez D, Builes M, et al.  Intragraft cytokine expression in heart transplants with mild or no histological rejection. Clin Transplant. 2001;15:228–235
  4. Pober JS, Cotran RS. The role of endothelial cells in inflammation. Transplantation. 1990;50:537
  5. Wilson AG, di Giovine FS, Blakemore AIF, Duff GW. Single base polymorphism in the human tumor necrosis factor alpha. (TNF-α) gene detected by Nco1 restriction of the PCR product Hum Mol Gen. 1992;1:353
  6. Wilson AG, Symons JA, McDowell TL, et al.  Effects of a tumor necrosis factor promoter base transition on transcriptional activity. Br J Rheumatol. 1994;33(suppl1):89; (TNF-α)
  7. Wilson AG, Giovine FS, Duff GW. Genetics of tumor necrosis factor in autoimmune, infectious, and neoplastic diseases. J Inflamm. 1995;45:1–12
  8. Danis V, Millington M, Hyland V, et al.  Increased frequency of the uncommon allele of a tumor necrosis factor α gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus. Dis Markers. 1994;12:127–133
  9. McGuire W, Hill AVS, Allsop CE, et al.  Variation in the TNF-α region associated with susceptibility to cerebral malaria. Nature. 1994;371:508–511
  10. Kubota T, McNamara DM, et al.  Effect of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. Circulation. 1998;97:2499–2501
  11. Densem CG, Hutchinson IV, Yonan N, et al.  Influence of tumor necrosis factor alpha gene-308 polymorphism on the development of coronary vasculopathy after cardiac transplantation. J Heart Lung Transplant. 2001;20:1265–1273
  12. Sankaran DA, Asderakis A, Ashraf S, et al.  Cytokine gene polymorphisms predict acute graft rejection following renal transplantation. Kidney Int. 1999;56:281–288
  13. Awad MR, Webber S, Boyle G, et al.  The effect of cytokine gene polymorphism on pediatric heart allograft outcome. J Heart Lung Transplant. 2001;20:625–630
  14. Billingham ME, Cary NR, Hammond ME, et al.  A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection (Heart Rejection Study Group). J Heart Transplant. 1990;9:587–593
  15. Everett JE, Djalilian AR, Kubo SH, et al.  Heart transplantation for patients over age 60. Clin Transplant. 1996;10:478–481
  16. Blanche C, Matloff JM, Denton TA, et al.  Heart transplantation in patients 70 years of age and older (Initial experience). Ann Thorac Surg. 1996;62:1731–1736
  17. Turner D, Grant SCD, Yonan N, et al. Cytokine gene polymorphism and heart transplant rejection. Transplantation 1997;64:776–8

☆ This study was supported in part by grants from the National Heart, Lung, and Blood Institute, Contracts RO1 HL 62300 (BL) and K24 HL 69912 (DM).

PII: S1053-2498(03)00346-2

doi: 10.1016/j.healun.2003.07.012

The Journal of Heart and Lung Transplantation
Volume 23, Issue 6 , Pages 696-700 , June 2004

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