The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 244-250 , February 2002

Up-regulation of Bcl-2 through hyperbaric pressure transfection of TGF-β1 ameliorates ischemia-reperfusion injury in rat cardiac allografts

Presented at the ISHLT 21st Annual Meeting and Scientific Sessions, April 25–28, 2001, Vancouver BC, Canada.

  • Jürg Grünenfelder, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    • Corresponding Author InformationReprint requests and correspondence: Jürg Grünenfelder, MD, Clinic for Cardiovascular Surgery, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. Telephone: 0041 1 255-3801. Fax: 0041 1 255-4369
    • ,
  • Douglas N Miniati, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    • ,
  • Seiichiro Murata, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    • ,
  • Volkmar Falk, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    • ,
  • E.Grant Hoyt

      Affiliations

    • Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA
    • ,
  • Robert C Robbins, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, California, USA

Received 13 July 2001 ,Accepted 29 August 2001.

References 

  1. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest. 1994;94:1621–1628
  2. Fliss H, Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res. 1996;79:949–956
  3. Cain BS, Meldrum DR, Dinarello CA, et al.  Tumor necrosis factor-alpha and interleukin-1 beta synergistically depress human myocardial function. (see comments) Crit Care Med. 1999;27:1309–1318
  4. Force T, Pombo CM, Avruch JA, Bonventre JV, Kyriakis JM. Stress-activated protein kinases in cardiovascular disease. Circ Res. 1996;78:947–953
  5. Lee L, Irani K, Finkel T. Bcl-2 regulates nonapoptotic signal transduction (inhibition of c-Jun N- terminal kinase (JNK) activation by IL-1beta and hydrogen peroxide). Mol Genet Metab. 1998;64:19–24
  6. Bach FH, Hancock WW, Ferran C. Protective genes expressed in endothelial cells (a regulatory response to injury). Immunol Today. 1997;18:483–486
  7. Bilbao G, Contreras JL, Eckhoff DE, et al.  Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene. Ann Surg. 1999;230:185–193
  8. Lefer AM, Tsao P, Aoki N, Palladino MA. Mediation of cardioprotection by transforming growth factor-β. Science. 1990;249:61–64
  9. Yang BC, Zander DS, Mehta JL. Hypoxia-reoxygenation-induced apoptosis in cultured adult rat myocytes and the protective effect of platelets and transforming growth factor-β1. J Pharmacol Exp Ther. 1999;291:733–738
  10. Yamamoto M, Maehara Y, Sakaguchi Y, Kusumoto T, Ichiyoshi Y, Sugimachi K. Transforming growth factor-beta 1 induces apoptosis in gastric cancer cells through a p53-independent pathway. Cancer. 1996;77:1628–1633
  11. Nagoshi S, Yasuda H, Suda J, et al.  Hepatocyte apoptosis and hepatic expression of transforming growth factor-beta1 mRNA during involution of hyperplastic rat liver induced by hepatocyte growth factor. J Gastroenterol Hepatol. 1998;13:786–793
  12. Henridrick-Noack P, Prehn JH, Krieglstein J. TGF-β1 protects hippocampal neurons against degeneration caused by transient global ischemia (Dose-response relationship and potential neuroprotective mechanisms). Stroke. 1996;27:1609–1614
  13. Mahmud N, Katayama N, Nishii K, et al.  Possible involvement of bcl-2 in regulation of cell-cycle progression of haematopoietic cells by transforming growth factor-beta1. Br J Haematol. 1999;105:470–477
  14. Pollman MJ, Hall JL, Mann MJ, Zhang L, Gibbons GH. Inhibition of neoinitmal cell bcl-x expression induces apoptosis and regression of vascular disease. Nature Med. 1998;4:222–227
  15. Poston RS, Ennen M, Pollard J, Hoyt EG, Robbins RC. Ex vivo gene therapy prevents chronic graft vascular disease in cardiac allografts. J Thorac Cardiovasc Surg. 1998;116:386–396
  16. Mann MJ, Gibbons GH, Hutchinson H, et al.  Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. Proc Natl Acad Sci USA. 1999;96:6411–6416
  17. Feeley BT, Poston RS, Park AK, et al.  Optimization of ex vivo pressure mediated delivery of antisense oligodeoxynucleotides to ICAM-1 reduces reperfusion injury in rat cardiac allografts. Transplantation. 2000;69:1067–1074
  18. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 1969;57:225–229
  19. Dunn JA, Li C, Ha T, Kao RL, Browder W. Therapeutic modification of nuclear factor kappa B binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis. Am Surg. 1997;63:1036–1044
  20. Maulik N, Yoshida T, Engelman RM, et al.  Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion. Mol Cell Biochem. 1998;186:139–145
  21. Ranges GE, Figari IS, Espevik T, Palladino MA. Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha. Exp Med. 1987;166:991–998
  22. Padua RR, Sethi R, Dhalla NS, Kardami E. Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury. Mol Cell Biochem. 1995;143:129–135
  23. Mehta JL, Yang BC, Strates BS, Mehta P. Role of TGF-β1 in platelet-mediated cardioprotection during ischemia-reperfusion in isolated rat hearts. Growth Factors. 1999;16:179–190
  24. Adams JM, Cory S. The bcl-2 protein family (arbiters of cell survival). Science. 1998;281:1322–1326
  25. Linette GP, Li Y, Roth K, Korsmeyer ST. Cross talk between cell death and cell cycle progression (bcl-2 regulates NFAT-mediated activation). Proc Natl Acad Sci U S A. 1996;93:9545–9552
  26. Miniati DN, Grunenfelder J, Hoyt EG, Murata S, Kown M, Koransky M, et al. Oxidative stress of cardiac transplantation is associated with decreased BCL-2 expression and increased NFKB activity. J Heart Lung Transplant. 2001;20:158–159

PII: S1053-2498(01)00377-1

The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 244-250 , February 2002

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