The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 211-216 , February 2002

Temporal changes in myocardial endothelial nitric oxide synthase expression following human heart transplantation

  • Niels G Vejlstrup, MD, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: Niels G Vejlstrup, MD, Medical Department B 2142, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Telephone: +45-35-45-23-47. Fax: +45-35-45-25-13
    • Medical Department B, Division of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Claus B Andersen, MD, PhD

      Affiliations

    • Medical Department B, Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Søren Boesgaard, MD, PhD,

      Affiliations

    • Medical Department B, Division of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Svend A Mortensen, MD, PhD,

      Affiliations

    • Medical Department B, Division of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Jan Aldershvile, MD, PhD

      Affiliations

    • Medical Department B, Division of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Received 30 April 2001 ,Accepted 16 July 2001.

References 

  1. Hosenpud JD, Bennett LE, Keck BM, et al.  The Registry of the International Society for Heart and Lung Transplantation (sixteenth official report--1999). J Heart Lung Transplant. 1999;18(7):611–616
  2. Kapadia SR, Ziada KM, L’Allier PL, et al.  Intravascular ultrasound imaging after cardiac transplantation (advantage of multi-vessel imaging). J Heart Lung Transplant. 2000;19(2):167–172
  3. Davies H, al Tikriti S. Coronary arterial pathology in the transplanted human heart. (see comments) Int J Cardiol. 1989;25(1):99–117
  4. Lee PC, Wang ZL, Qian S, et al.  Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis. Transplantation. 2000;69(6):1186–1192
  5. Ignarro LJ, Buga GM, Wood KS, et al.  Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987;84(24):9265–9269
  6. Radomski MW, Moncada S. The biological and pharmacological role of nitric oxide in platelet function. Adv Exp Med Biol. 1993;344:251–264
  7. Kubes P, Suzuki M, Granger DN. Nitric oxide (an endogenous modulator of leukocyte adhesion). Proc Natl Acad Sci U S A. 1991;88(11):4651–4655
  8. der Leyen HE, Gibbons GH, Morishita R, et al.  Gene therapy inhibiting neointimal vascular lesion (in vivo transfer of endothelial cell nitric oxide synthase gene). Proc Natl Acad Sci U S A. 1995;92(4):1137–1141
  9. Tzeng E, Shears LL, Robbins PD, et al.  Vascular gene transfer of the human inducible nitric oxide synthase (characterization of activity and effects on myointimal hyperplasia). Mol Med. 1996;2(2):211–225
  10. Pollock JS, Nakane M, Buttery LD, et al.  Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol. 1993;265:C1379–C1387
  11. Vejlstrup NG, Bouloumie A, Boesgaard S, et al.  Inducible nitric oxide synthase (iNOS) in the human heart (expression and localization in congestive heart failure). J Mol Cell Cardiol. 1998;30(6):1215–1223
  12. Davis SF, Yeung AC, Meredith IT, et al.  Early endothelial dysfunction predicts the development of transplant coronary artery disease at 1 year posttransplant. Circulation. 1996;93(3):457–462
  13. Andersen HO, Qvortrup K, Rostgaard J, Nordestgaard BG. Effect of cyclosporine during initiation of transplant arteriosclerosis. An ultrastructural study in the aorta-transplanted rabbit. Atherosclerosis. 1997;133(2):171–181
  14. Flowers MA, Wang Y, Stewart RJ, et al.  Reciprocal regulation of endothelin-1 and endothelial constitutive NOS in proliferating endothelial cells. Am J Physiol. 1995;269:H1988–H1997
  15. Myers PR, Webel R, Thondapu V, et al.  Restenosis is associated with decreased coronary artery nitric oxide synthase. Int J Cardiol. 1996;55(2):183–191
  16. Liu SF, Adcock IM, Old RW, et al.  Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysaccharide treatment in vivo in the rat. Crit Care Med. 1996;24(7):1219–1225
  17. Nishida K, Harrison DG, Navas JP, et al.  Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 1992;90(5):2092–2096
  18. Lamas S, Marsden PA, Li GK, et al.  Endothelial nitric oxide synthase (molecular cloning and characterization of a distinct constitutive enzyme isoform). Proc Natl Acad Sci U S A. 1992;89(14):6348–6352
  19. Arnal JF, Yamin J, Dockery S, Harrison DG. Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am J Physiol. 1994;267:C1381–C1388
  20. Barna M, Komatsu T, Reiss CS. Activation of type III nitric oxide synthase in astrocytes following a neurotropic viral infection. Virology. 1996;223(2):331–343
  21. Bucher M, Ittner KP, Zimmermann M, et al.  Nitric oxide synthase isoform III gene expression in rat liver is up-regulated by lipopolysaccharide and lipoteichoic acid. FEBS Lett. 1997;412(3):511–514
  22. Forstermann U, Boissel JP, Kleinert H. Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J. 1998;1a2(10):773–790
  23. Szabolcs MJ, Ravalli S, Minanov O, et al.  Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection. Transplantation. 1998;65(6):804–812
  24. Lewis NP, Tsao PS, Rickenbacher PR, et al.  Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. Circulation. 1996;93(4):720–729
  25. Buga GM, Griscavage JM, Rogers NE, Ignarro LJ. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res. 1993;73(5):808–812
  26. Bult H, De Meyer GR, Herman AG. Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta. Br J Pharmacol. 1995;114(7):1371–1382
  27. Drexler H, Fischell TA, Pinto FJ, et al.  Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology. Circulation. 1994;89(4):1615–1623
  28. Laufs U, Fata LV, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998;97(12):1129–1135
  29. Hosenpud JD, Bennett LE, Keck BM, et al.  The Registry of the International Society for Heart and Lung Transplantation (fourteenth official report-1997). J Heart Lung Transplant. 1997;16(7):691–712

PII: S1053-2498(01)00359-X

The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 211-216 , February 2002

Article Tools

* Image Usage & Resolution