The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 233-243 , February 2002

A novel small animal model of left ventricular tissue engineering

  • Alexander S Krupnick, MD

      Affiliations

    • Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    • ASK and DK contributed equally to this work and should be considered co-first authors.
  • ,
  • Daniel Kreisel, MD

      Affiliations

    • Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    • ASK and DK contributed equally to this work and should be considered co-first authors.
  • ,
  • Friederike H Engels, MD

      Affiliations

    • Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
  • ,
  • Wilson Y Szeto, MD

      Affiliations

    • Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
  • ,
  • Theodore Plappert, CVT

      Affiliations

    • Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
  • ,
  • Sicco H Popma, PhD

      Affiliations

    • Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
  • ,
  • Alan W Flake, MD

      Affiliations

    • Department of Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
  • ,
  • Bruce R Rosengard, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Bruce R. Rosengard, MD, Division of Cardiothoracic Surgery, 6 Silverstein, Department of Surgery, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 USA Telephone: 215-662-4765. Fax: 215-349-5798
    • Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA

References 

  1. Srivastava D, Olson EN. A genetic blueprint for cardiac development. Nature. 2000;407:221–226
  2. Tchervenkov CI, Jacobs ML, Tahta SA. Congenital heart surgery nomenclature and database project (hypoplastic left heart syndrome). Ann Thorac Surg. 2000;69:170–179
  3. Langer R, Vacanti JP. Tissue engineering. Science. 1993;260:920–926
  4. Niklason LE, Gao J, Abbott WM, et al.  Functional arteries grown in vitro. [see comments] Science. 1999;284:489–493
  5. Shinoka T, Breuer CK, Tanel RE, et al.  Tissue engineering heart valves (Valve leaflet replacement study in a lamb model). Ann Thorac Surg. 1995;60(suppl):S513–S516
  6. Hoerstrup SP, Sodian R, Sperling JS, Vacanti JP, Mayer JE. New pulsatile bioreactor for in vitro formation of tissue engineered heart valves. Tissue Eng. 2000;6:75–79
  7. Shinoka T, Ma PX, Shum-Tim D, et al.  Tissue-engineered heart valves. Autologous valve leaflet replacement study in a lamb model. Circulation. 1996;94(suppl):II164–II168
  8. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276:71–74
  9. Zimmermann WH, Fink C, Kralisch D, Remmers U, Weil J, Eschenhagen T. Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. Biotechnol Bioeng. 2000;68:106–114
  10. Asfour B, Hare JM, Kohl T, et al.  A simple new model of physiologically working heterotopic rat heart transplantation provides hemodynamic performance equivalent to that of an orthotopic heart. J Heart Lung Transplant. 1999;18:927–936
  11. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 1969;57:225–229
  12. Schiller NB, Shah PM, Crawford M, et al.  Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American society of echocardiography committee on standards, subcommittee on quantitation of two-dimensional echocardiograms. J Am Soc Echocardiogr. 1989;2:358–367
  13. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve. 1995;18:1417–1426
  14. Pittenger MF, Mackay AM, Beck SC, et al.  Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–147
  15. Sakai T, Li RK, Weisel RD, et al.  Autologous heart cell transplantation improves cardiac function after myocardial injury. Ann Thorac Surg. 1999;68:2074–2081
  16. Li RK, Jia ZQ, Weisel RD, Merante F, Mickle DA. Smooth muscle cell transplantation into myocardial scar tissue improves heart function. J Mol Cell Cardiol. 1999;31:513–522
  17. Klug MG, Soonpaa MH, Koh GY, Field LJ. Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts. J Clin Invest. 1996;98:216–224
  18. Sakata J, Vacanti CA, Schloo B, Healy GB, Langer R, Vacanti JP. Tracheal composites tissue engineered from chondrocytes, tracheal epithelial cells, and synthetic degradable scaffolding. Transplant Proc. 1994;26:3309–3310
  19. Kaihara S, Vacanti JP. Tissue engineering (toward new solutions for transplantation and reconstructive surgery). Arch Surg. 1999;134:1184–1188
  20. Juang JH, Bonner-Weir S, Ogawa Y, Vacanti JP, Weir GC. Outcome of subcutaneous islet transplantation improved by polymer device. Transplantation. 1996;61:1557–1561
  21. Mooney DJ, Breuer CK, McNamara K, Vacanti JP, Langer R. Fabricating tubular devices from polymers of lactic and glycolic acid for tissue engineering. Tissue Eng. 1995;1:107–118
  22. Peters MC, Mooney DJ. Synthetic extracellular matrices for cell transplantation. In:  Liu DM,  Dixit V editor. Materials science forum. Vol 250:Switzerland: Trans Tech Publications; 1997;p. 43–52
  23. Krupnick AS, Shabaan A, Radu A, Flake AW. Bone marrow tissue engineering. Tissue Engineering In Press. 2001;
  24. Eaton LW, Weiss JL, Bulkley BH, Garrison JB, Weisfeldt ML. Regional cardiac dilatation after acute myocardial infarction (Recognition by two-dimensional echocardiography). N Engl J Med. 1979;300:57–62
  25. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81:1161–1172
  26. Mankani MH, Krebsbach PH, Satomura K, Kuznetsov SA, Hoyt R, Robey PG. Pedicled bone flap formation using transplanted bone marrow stromal cells. Arch Surg. 2001;36:263–270
  27. Soonpaa MH, Koh GY, Klug MG, Field LJ. Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. [see comments] Science. 1994;264:98–101
  28. Koh GY, Soonpaa MH, Klug MG, et al.  Stable fetal cardiomyocyte grafts in the hearts of dystrophic mice and dogs. J Clin Invest. 1995;96:2034–2042
  29. Pfeffer MA, Pfeffer JM, Fishbein MC, et al.  Myocardial infarct size and ventricular function in rats. Circ Res. 1979;44:503–512
  30. Liechty KW, MacKenzie TC, Shaaban AF, et al.  Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Med. 2000;6:1282–1286
  31. Tomita S, Li RK, Weisel RD, et al.  Autologous transplantation of bone marrow cells improves damaged heart function. Circulation. 1999;100:II247–II256
  32. Orlic D, Kajstura J, Chimenti S, et al.  Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705
  33. Brodsky WY, Arefyeva AM, Uryvaeva IV. Mitotic polyploidization of mouse heart myocytes during the first postnatal week. Cell Tissue Res. 1980;210:133–144
  34. Clubb FJ, Bishop SP. Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy. Lab Invest. 1984;50:571–577
  35. Bellotto F, Johnson RG, Watanabe J, Levine MJ, Franklin A, Weintraub RM. Mechanical assistance of the left ventricle (acute effect on cardiac performance and coronary flow of different perfusion patterns). J Thorac Cardiovasc Surg. 1992;104:561–568
  36. Bruckner BA, Stetson SJ, Perez-Verdia A, et al.  Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant. 2001;20:457–464
  37. Feinendegen LE, Heiniger HJ, Friedrich G, Cronkite EP. Differences in reutilization of thymidine in hemopoietic and lymphopoietic tissues of the normal mouse. Cell Tissue Kinet. 1973;6:573–585
  38. Forster I, Rajewsky K. The bulk of the peripheral b-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc Natl Acad Sci USA. 1990;87:4781–4784
  39. Kaihara S, Borenstein J, Koka R, et al.  Silicon micromachining to tissue engineer branched vascular channels for liver fabrication. Tissue Eng. 2000;6:105–117
  40. Shea LD, Smiley E, Bonadio J, Mooney DJ. DNA delivery from polymer matrices for tissue engineering. [see comments] [published erratum appears in nat biotechnol 1999 aug;17(8):817] Nat Biotechnol. 1999;17:551–554
  41. Lee KY, Peters MC, Anderson KW, Mooney DJ. Controlled growth factor release from synthetic extracellular matrices. Nature. 2000;408:998–1000

 Supported in part by grants from the NIH, the University of Pennsylvania Research Foundation, American Society of Transplant Surgeons, and the Center For Innovative Minimally Invasive Therapy.

PII: S1053-2498(01)00349-7

The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 233-243 , February 2002