The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 282-285 , February 2002

Mycophenolate mofetil decreases antibody production after cardiac transplantation

  • Marlene L Rose, PhD

      Affiliations

    • Imperial College School of Medicine, Harefield Hospital, Harefield, UK
    • Corresponding Author InformationReprint requests: Prof. Marlene L. Rose, National Heart and Lung Institute, Imperial College School of medicine, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK. Telephone: 44-1-895-828-575. Fax: 44-1-895-828-900
    • ,
  • John Smith, BSc

      Affiliations

    • Imperial College School of Medicine, Harefield Hospital, Harefield, UK
    • ,
  • Georges Dureau, MD

      Affiliations

    • Hopitaux de Lyon, Lyon, France
    • ,
  • Anne Keogh, MD

      Affiliations

    • St Vincent’s Hospital, Darlinghurst, Sydney, Australia
    • ,
  • Jon Kobashigowa, MD

      Affiliations

    • UCLA Medical Center, Los Angeles, California, USA

Received 6 March 2001 ,Accepted 1 June 2001.

References 

  1. Hosenpud JD, Bennett LE, Keck BM, Boucek MM, Novick RJ. The registry of the International Society for Heart and Lung Transplantation (seventeenth official report—2000). J Heart Lung Transplant. 2000;19:909–931
  2. Rose ML. Role of antibody in rejection. Curr Opin Organ Transplant. 1999;4:227–233
  3. Constanzo MR, Naftel DC, Protzer MR, et al.  Heart transplant coronary artery disease detected by coronary angiography (a multiinstitutional study of pre-operative donor and recipient risk factors). J Heart Lung Transplant. 1998;17:744–753
  4. Reed EF, Hong B, Ho E, Harris PE, Weinberger J, Suciu-Foca N. Monitoring of soluble HLA alloantigens and anti-HLA antibodies identifies heart allograft recipients at risk of transplant associated coronary artery disease. Transplantation. 1996;61:556
  5. Dunn MJ, Crisp S, Rose ML, Taylor P, Yacoub MH. Anti-endothelial antibodies and coronary artery disease after cardiac transplantation. Lancet. 1992;339:1566
  6. Wicker LS, Boltz RC, Matt V, Nichols EA, Peterson LB, Sigal NH. Suppression of B cell activation by cyclosporin A, FK506 and rapamycin. Eur J Immunol. 1990;20:2277–2283
  7. Gummert JF, Ikonen T, Morris RE. Newer immunosuppressive drugs (a review). J Am Soc Nephrol. 1999;10:1366–1380
  8. Eugui EM, Mirkovich A, Allison AC. Lymphocyte selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice. Scand J Immunol. 1991;33:175–183
  9. Eugui EM, Almquist SJ, Muller CD, Allison AC. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro (role of deoxyguanosine nucleotide depletion). Scand J Immunol. 1991;33:161
  10. Klaus GGB. Cyclosporine-sensitive and cyclosporine-insensitive modes of B cell stimulation. Transplantation. 1988;46(suppl):11S–14S
  11. Smith KGC, Isbel NM, Catton MG, Leydon JA, Becker GJ, Walker RG. Suppression of the humoral immune response by mycophenolate mofetil. Nephrol Dial Transplant. 1998;13:160–164
  12. Kobashigowa J, Miller L, Renlund D, et al.  a randomised active-controlled trial of mycophenolate mofetil in heart transplant recipients. Transplantation. 1998;66:507
  13. Jurcevic S, Dunn MJ, Crisp SJ, Busing K, Rinaldi M, Pelligegrini C, et al. A new enzyme linked immunosorbent assay to measure anti-endothelial antibodies after cardiac transplantation demonstrates greater inhibition of antibody formation by tacrolimus compared to cyclosporine. Transplantation. 1998;65:1197
  14. Jurcevic S, Ainsworth M, Pomerance A, Smith JD, Robinson RD, Dunn MJ, et al. Anti-vimentin antibodies are an independent predictor of transplant associated coronary artery disease following cardiac transplantation. Transplantation. 2001;71:886–892
  15. Schiffers PMH, Henrion D, Boulanger CM, et al.  Altered flow-induced arterial remodelling in vimentin deficient mice. Arterioscler Thromb Vasc Biol. 2000;20:611–616
  16. Helmke BP, Goldman RD, Davies PF. Rapid dispacement of vimentin intermediate filaments in living endothelial cells exposed to flow. Circ Res. 2000;86:745–752
  17. Klein NJ, Rigley KP, Callard RE. IL-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells (relationship between vimentin and CD23). Int Immunol. 1993;3:293–301

PII: S1053-2498(01)00335-7

The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 282-285 , February 2002

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