The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 282-285, February 2002

Mycophenolate mofetil decreases antibody production after cardiac transplantation

  • Marlene L Rose, PhD

      Affiliations

    • Imperial College School of Medicine, Harefield Hospital, Harefield, UK
    • Corresponding Author InformationReprint requests: Prof. Marlene L. Rose, National Heart and Lung Institute, Imperial College School of medicine, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK. Telephone: 44-1-895-828-575. Fax: 44-1-895-828-900
    • ,
  • John Smith, BSc

      Affiliations

    • Imperial College School of Medicine, Harefield Hospital, Harefield, UK
    • ,
  • Georges Dureau, MD

      Affiliations

    • Hopitaux de Lyon, Lyon, France
    • ,
  • Anne Keogh, MD

      Affiliations

    • St Vincent’s Hospital, Darlinghurst, Sydney, Australia
    • ,
  • Jon Kobashigowa, MD

      Affiliations

    • UCLA Medical Center, Los Angeles, California, USA

Received 6 March 2001; accepted 1 June 2001.

Abstract 

New immunosuppressive drugs are extensively being investigated for their effect on T-cell immunity, with far less being known about their effect on the humoral immune response. In view of the experimental and clinical evidence that humoral immunity contributes to acute and chronic rejection, we investigated post-transplant production of anti-vimentin and anti-HLA antibodies in 86 patients who were part of a worldwide clinical trial for mycophenolate mofetil in cardiac transplantation. The results demonstrate that patients taking MMF instead of azathioprine generated significantly fewer de novo anti-vimentin antibodies.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1053-2498(01)00335-7

The Journal of Heart and Lung Transplantation
Volume 21, Issue 2 , Pages 282-285, February 2002

Article Tools