Successful Outcome of Human Metapneumovirus (hMPV) Pneumonia in a Lung Transplant Recipient Treated With Intravenous Ribavirin

Raza, Kashif; Ismailjee, Sameer B.; Crespo, Maria; Studer, Sean M.; Sanghavi, Sonali; Paterson, David L.; Kwak, Eun J.; Rinaldo, Charles R.; Pilewski, Joseph M.; McCurry, Kenneth R.; Husain, Shahid

doi:10.1016/j.healun.2007.05.020

« Previous Next »The Journal of Heart and Lung Transplantation
Volume 26, Issue 8 , Pages 862-864, August 2007

Successful Outcome of Human Metapneumovirus (hMPV) Pneumonia in a Lung Transplant Recipient Treated With Intravenous Ribavirin

Kashif Raza, MD
- Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Sameer B. Ismailjee, MD
- Wright School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Maria Crespo, MD
- Division of Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Sean M. Studer, MD
- Division of Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Sonali Sanghavi, PhD
- Clinical Virology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
David L. Paterson, MD
- Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Eun J. Kwak, MD
- Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Charles R. Rinaldo Jr, PhD
- Clinical Virology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Joseph M. Pilewski, MD
- Division of Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Kenneth R. McCurry, MD
- Division of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Shahid Husain, MD, MS
- Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
- Reprint requests: Shahid Husain, MD, Transplant Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building, Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213. Telephone: 412-648-6442. Fax: 412-648-6399.

Received 5 February 2007; received in revised form 16 May 2007; accepted 28 May 2007. published online 15 July 2007.

Human metapneumovirus (hMPV) has recently been shown to be a prominent cause of respiratory infections in immunocompromised hosts, and is associated with high morbidity and mortality. We report a case of hMPV pneumonia in a lung transplant recipient presenting with respiratory failure and sepsis syndrome. hMPV was diagnosed by polymerase chain reaction, and treated with intravenous ribavirin with a successful outcome.